Quantifying iron content in magnetic resonance imaging

被引：76
作者：
Ghassaban, Kiarash [1 ]
Liu, Saifeng [2 ]
Jiang, Caihong [3 ]
Haacke, E. Mark [1 ,2 ,4 ]
机构：
[1] Magnet Resonance Innovat Inc, Bingham Farms, MI 48025 USA
[2] MRI Inst Biomed Res, Bingham Farms, MI 48025 USA
[3] Shanghai World Foreign Language Acad, Shanghai, Peoples R China
[4] Wayne State Univ, Dept Radiol, 3990 John R St, Detroit, MI 48201 USA
来源：
NEUROIMAGE | 2019年 / 187卷
关键词：
Magnetic resonance imaging; Iron quantification; Multiple sclerosis; Parkinson's disease; Iron tagged cells; USPIO contrast agents; SUSCEPTIBILITY MAPPING QSM; MULTIPLE-SCLEROSIS LESIONS; MESENCHYMAL STEM-CELLS; DEEP GRAY-MATTER; TRANSFUSION-DEPENDENT THALASSEMIA; ENDOTHELIAL PROGENITOR CELLS; BACKGROUND FIELD REMOVAL; CEREBRAL BLOOD-VOLUME; CONTRAST-ENHANCED MRI; IN-VIVO TRACKING;
D O I：
10.1016/j.neuroimage.2018.04.047
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Measuring iron content has practical clinical indications in the study of diseases such as Parkinson's disease, Huntington's disease, ferritinopathies and multiple sclerosis as well as in the quantification of iron content in microbleeds and oxygen saturation in veins. In this work, we review the basic concepts behind imaging iron using T2, T2*, T2', phase and quantitative susceptibility mapping in the human brain, liver and heart, followed by the applications of in vivo iron quantification in neurodegenerative diseases, iron tagged cells and ultra-small superparamagnetic iron oxide (USPIO) nanoparticles.
引用
收藏
页码：77 / 92
页数：16
相关论文
共 221 条
[1]   Development of a Tumor-Selective Approach to Treat Metastatic Cancer [J].
Aboody, Karen S. ;
Bush, Rebecca A. ;
Garcia, Elizabeth ;
Metz, Marianne Z. ;
Najbauer, Joseph ;
Justus, Kristine A. ;
Phelps, Doris A. ;
Remack, Joanna S. ;
Yoon, Karina Jin ;
Gillespie, Shanna ;
Kim, Seung U. ;
Glackin, Carlotta A. ;
Potter, Philip M. ;
Danks, Mary K. .
PLOS ONE, 2006, 1 (01)
[2]   Targeting of melanoma brain metastases using engineered neural stem/progenitor cells [J].
Aboody, KS ;
Najbauer, J ;
Schmidt, NO ;
Yang, W ;
Wu, JK ;
Zhuge, Y ;
Przylecki, W ;
Carroll, R ;
Black, PM ;
Perides, G .
NEURO-ONCOLOGY, 2006, 8 (02) :119-126
[3]   The whole-brain pattern of magnetic susceptibility perturbations in Parkinson's disease [J].
Acosta-Cabronero, Julio ;
Cardenas-Blanco, Arturo ;
Betts, Matthew J. ;
Butryn, Michaela ;
Valdes-Herrera, Jose P. ;
Galazky, Imke ;
Nestor, Peter J. .
BRAIN, 2017, 140 :118-131
[4]   Chemistry and biology of eukaryotic iron metabolism [J].
Aisen, P ;
Enns, C ;
Wessling-Resnick, M .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2001, 33 (10) :940-959
[5]   Assessment of Iron Overload with T2*Magnetic Resonance Imaging [J].
Anderson, Lisa J. .
PROGRESS IN CARDIOVASCULAR DISEASES, 2011, 54 (03) :287-294
[6]   Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload [J].
Anderson, LJ ;
Holden, S ;
Davis, B ;
Prescott, E ;
Charrier, CC ;
Bunce, NH ;
Firmin, DN ;
Wonke, B ;
Porter, J ;
Walker, JM ;
Pennell, DJ .
EUROPEAN HEART JOURNAL, 2001, 22 (23) :2171-2179
[7]  
[Anonymous], NMR BIOMED
[8]   A model of lysosomal metabolism of dextran coated superparamagnetic iron oxide (SPIO) nanoparticles: implications for cellular magnetic resonance imaging [J].
Arbab, AS ;
Wilson, LB ;
Ashari, P ;
Jordan, EK ;
Lewis, BK ;
Frank, JA .
NMR IN BIOMEDICINE, 2005, 18 (06) :383-389
[9]   Ferritin, iron homeostasis, and oxidative damage [J].
Arosio, P ;
Levi, S .
FREE RADICAL BIOLOGY AND MEDICINE, 2002, 33 (04) :457-463
[10]   Nigral Iron Elevation Is an Invariable Feature of Parkinson's Disease and Is a Sufficient Cause of Neurodegeneration [J].
Ayton, Scott ;
Lei, Peng .
BIOMED RESEARCH INTERNATIONAL, 2014, 2014
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