Transplantation of oligodendrocyte precursor cells improves myelination and promotes functional recovery after spinal cord injury

被引：31
|
作者：
Wu, Bo [2 ]
Sun, Lei [2 ]
Li, Peijia [2 ]
Tian, Min [2 ]
Luo, Yongzhong [2 ]
Ren, Xianjun [1 ]
机构：
[1] Third Mil Med Univ, Dept Orthoped, Xinqiao Hosp, Chongqing, Peoples R China
[2] 88th Hosp, Dept Orthoped, Tai An, Shandong, Peoples R China
来源：
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED | 2012年 / 43卷 / 06期
关键词：
Oligodendrocyte precursor cell; Cell transplantation; Demyelination; Therapeutics; Spinal cord injury; Rats; CENTRAL-NERVOUS-SYSTEM; PROGENITOR CELLS; STEM-CELLS; DEMYELINATION; REMYELINATION; REPAIR; DEATH; RATS; DEGENERATION; SURVIVAL;
D O I：
10.1016/j.injury.2011.09.013
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Loss of oligodendrocytes and demyelination further impair neural function after spinal cord injury (SCI). Replacement of lost oligodendrocytes and improvement of myelination have a therapeutic significance in treatment of SCI. Here, we transplanted oligodendrocyte precursor cells (OPCs) to improve myelination in a rat model of contusive SCI. The labelled OPCs were transplanted to injured cord 7 days after injury. As a result, the implanted cells still survived in vivo 8 weeks after transplantation. They proliferated, integrated and differentiated in the injured cord. In the OPCs-treated rats, enhanced myelination in the lesioned area was observed and substantial improvement of motor function and nerve conduction was also recorded. Thus, this study provides strong evidence to support that transplantation of OPCs could improve myelination of injured cord and enhance functional recovery after contusive SCI. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：794 / 801
页数：8
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