Preparation and characterization of collagen/chitosan poly (ethylene glycol)/nanohydroxyapatite composite scaffolds

被引：12

作者：

Kozlowska, Justyna ^{[1
]}

Stachowiak, Natalia ^{[1
]}

Sionkowska, Alina ^{[1
]}

机构：

[1] Nicolaus Copernicus Univ Torun, Fac Chem, Gagarina 7, PL-87100 Torun, Poland

来源：

POLYMERS FOR ADVANCED TECHNOLOGIES | 2019年 / 30卷 / 03期

关键词：

chitosan; collagen; composite materials; hydroxyapatite; poly (ethylene glycol); HYDROXYAPATITE SCAFFOLDS; BONE; COLLAGEN; BIOMATERIALS; CHITOSAN; CELLS;

D O I：

10.1002/pat.4506

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Porous three-dimensional collagen/chitosan scaffolds combined with poly (ethylene glycol) (PEG) and hydroxyapatite were obtained through a freeze-drying method. Physical cross-linking was examined by dehydrothermal treatment. The prepared materials were characterized by different analyses, eg, scanning electron microscopy (SEM), measurements of porosity and swelling, mechanical properties, and resistance to enzymatic degradation. The porosity of scaffolds and their swelling ratio decreased with the addition of hydroxyapatite. Moreover, after exposure to collagenase, the collagen/chitosan matrices containing PEG showed much faster degradation rate than matrices with the addition of hydroxyapatite. The results indicated that the addition of hydroxyapatite led to improvement of stiffness. The highest degree of porosity and swelling were demonstrated by collagen/chitosan/PEG matrices without hydroxyapatite.

引用

页码：799 / 803

页数：5

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