Risk of digital ulcers occurrence in systemic sclerosis: a cross-sectional study

被引：8
作者：
Coelho Horimoto, Alex Magno [1 ]
de Souza, Albert Schiaveto [2 ]
Rodrigues, Silvia Helena [3 ]
Kayser, Cristiane [3 ]
机构：
[1] Univ Fed Mato Grosso do Sul UFMS, Rheumatol Div, Av Senador Filinto Muller S-N, BR-79080190 Campo Grande, MS, Brazil
[2] Univ Fed Mato Grosso do Sul, Inst Biosci, Campo Grande, MS, Brazil
[3] Univ Fed Sao Paulo, Escola Paulista Med, Rheumatol Div, Sao Paulo, Brazil
来源：
ADVANCES IN RHEUMATOLOGY | 2019年 / 59卷
关键词：
Systemic sclerosis; Digital ulcers; Capillaroscopy; Autoantibodies; HEALTH-ASSESSMENT QUESTIONNAIRE; DISEASE-ACTIVITY; ANTIPHOSPHOLIPID ANTIBODIES; NAILFOLD CAPILLAROSCOPY; FUNCTIONAL STATUS; VASCULAR-DISEASE; SCLERODERMA; SEVERITY; MULTICENTER; INDEX;
D O I：
10.1186/s42358-019-0057-9
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background/objective: Digital ulcers (DUs) represent a frequent complication of systemic sclerosis (SSc). The aim of this study was to evaluate clinical, serological and capillaroscopy features that are associated with DUs in patients with SSc. Methods: In this bicentric cross-sectional study, 70 patients with SSc were consecutively selected from March 2016 to April 2017. Demographic and clinical features, including the presence of active DUs, were collected. Videocapillaroscopy was performed in all patients. Results: Among the 70 patients included (mean age of 46.8 years, mean disease duration of 9.41 years), 14 (20%) had active DUs. Based on multivariate analysis, the presence of anti-Scl-70 antibodies, the HAQ-DI score, and the capillary loss score were independently associated with DUs with odds ratios of 7.96 (95% CI 1.32-47.99), 55.77 (95% CI 1.76-1764.28), and 16.66 (95% CI 2.07-133.81), respectively. Conclusions: The presence of avascular areas in capillaroscopy, elevation of HAQ-DI score and anti-Scl-70 antibodies were independent factors associated with DUs in patients with SSc.
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页数：7
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