An adduct between peroxynitrite and 2'-deoxyguanosine: 4,5-dihydro-5-hydroxy-4-(nitrosooxy)-2'-deoxyguanosine

被引：96

作者：

Douki, T ^{[1
]}

Cadet, J ^{[1
]}

Ames, BN ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY, DIV BIOCHEM & MOLEC BIOL, BERKELEY, CA 94720 USA

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 1996年 / 9卷 / 01期

关键词：

NITRIC-OXIDE; SUPEROXIDE-DISMUTASE; NITRATION; OXIDANTS;

D O I：

10.1021/tx950126n

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The reactivity of peroxynitrite (OONO-) with DNA is of interest because it is released during chronic inflammation, a major contributor to cancer. Peroxynitrite was found to undergo homolytic addition to the C4-C5 double bond of 2'-deoxyguanosine with formation of 4,5-dihydro-5-hydroxy-4-(nitrosooxy)-2'-deoxyguanosine (nox-dG). This adduct may be a useful marker in the study of the chemical processes associated with the mutagenicity of peroxynitrite.

引用

页码：3 / 7

页数：5

共 38 条

[1] THE CAUSES AND PREVENTION OF CANCER [J].

AMES, BN ;

GOLD, LS ;

WILLETT, WC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (12) :5258-5265

[2] OXIDANTS, ANTIOXIDANTS, AND THE DEGENERATIVE DISEASES OF AGING [J].

AMES, BN ;

SHIGENAGA, MK ;

HAGEN, TM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) :7915-7922

[3] MUTAGENICITY OF NITRIC-OXIDE AND ITS INHIBITION BY ANTIOXIDANTS [J].

ARROYO, PL ;

HATCHPIGOTT, V ;

MOWER, HF ;

COONEY, RV .

MUTATION RESEARCH, 1992, 281 (03) :193-202

[4] APPARENT HYDROXYL RADICAL PRODUCTION BY PEROXYNITRITE - IMPLICATIONS FOR ENDOTHELIAL INJURY FROM NITRIC-OXIDE AND SUPEROXIDE [J].

BECKMAN, JS ;

BECKMAN, TW ;

CHEN, J ;

MARSHALL, PA ;

FREEMAN, BA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1620-1624

[5] ALS, SOD AND PEROXYNITRITE [J].

BECKMAN, JS ;

CARSON, M ;

SMITH, CD ;

KOPPENOL, WH .

NATURE, 1993, 364 (6438) :584-584

[6] KINETICS OF SUPEROXIDE DISMUTASE-CATALYZED AND IRON-CATALYZED NITRATION OF PHENOLICS BY PEROXYNITRITE [J].

BECKMAN, JS ;

ISCHIROPOULOS, H ;

ZHU, L ;

VANDERWOERD, M ;

SMITH, C ;

CHEN, J ;

HARRISON, J ;

MARTIN, JC ;

TSAI, M .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1992, 298 (02) :438-445

[7] REACTION OF SUPEROXIDE WITH NITRIC-OXIDE TO FORM PEROXONITRITE IN ALKALINE AQUEOUS-SOLUTION [J].

BLOUGH, NV ;

ZAFIRIOU, OC .

INORGANIC CHEMISTRY, 1985, 24 (22) :3502-3504

[8] THE COMPARATIVE TOXICITY OF NITRIC-OXIDE AND PEROXYNITRITE TO ESCHERICHIA-COLI [J].

BRUNELLI, L ;

CROW, JP ;

BECKMAN, JS .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1995, 316 (01) :327-334

[9] DETECTION OF DEOXYRIBONUCLEOSIDES ON PAPER CHROMATOGRAMS [J].

BUCHANAN, JG .

NATURE, 1951, 168 (4286) :1091-1091

[10] 2,2-DIAMINO-4-[(3,5-DI-O-ACETYL-2-DEOXY-BETA-D-ERYTHROPENTOFURANOSYL) AMINO]-5-(2H)-OXAZOLONE - A NOVEL AND PREDOMINANT RADICAL OXIDATION-PRODUCT OF 3',5'-DI-O-ACETYL-2'-DEOXYGUANOSINE [J].

CADET, J ;

BERGER, M ;

BUCHKO, GW ;

JOSHI, PC ;

RAOUL, S ;

RAVANAT, JL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (16) :7403-7404

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