Perilipin 2 and Age-Related Metabolic Diseases: A New Perspective

被引：107

作者：

Conte, Maria ^{[1
,2
]}

Franceschi, Claudio ^{[3
]}

Sandri, Marco ^{[4
,5
]}

Salvioli, Stefano ^{[1
,2
]}

机构：

[1] Univ Bologna, Dept Expt Diagnost & Specialty Med DIMES, I-40126 Bologna, Italy

[2] Univ Bologna, Interdept Ctr L Galvani CIG, I-40126 Bologna, Italy

[3] IRCCS, Inst Neurol Sci Bologna, I-40139 Bologna, Italy

[4] Univ Padua, Dept Biomed Sci, I-35121 Padua, Italy

[5] Venetlan Inst Mol Med, I-35129 Padua, Italy

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2016年 / 27卷 / 12期

基金：

欧盟地平线“2020”;

关键词：

CHAPERONE-MEDIATED AUTOPHAGY; DROPLET-ASSOCIATED PROTEINS; REGULATES LIPID-METABOLISM; DIET-INDUCED OBESITY; INSULIN-RESISTANCE; SKELETAL-MUSCLE; GENE-EXPRESSION; ANTISENSE OLIGONUCLEOTIDE; HEPATIC STEATOSIS; MASS-SPECTROMETRY;

D O I：

10.1016/j.tem.2016.09.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Perilipin 2 (Plin2), a protein associated with the metabolism of intracellular lipid droplets (LDs), has long been considered only for its role in lipid storage. However, the manipulation of its expression affects the severity of a variety of metabolic and age-related diseases, such as fatty liver, insulin resistance and type 2 diabetes (T2D), cardiovascular disease, atherosclerosis, sarcopenia, and cancer, suggesting that this protein may play a role in these pathological conditions. In particular, its downregulation in mice prevents or mitigates some of the above mentioned diseases. Conversely, in humans high levels of Plin2 are present in sarcopenia, hepatic steatosis, atherosclerosis, and some types of cancer. We propose that inhibition of Plin2 might be a strategy to counteract several metabolic and age-related diseases.

引用

页码：893 / 903

页数：11

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