Identification and development of 2,5-disubstituted oxadiazole as potential candidate for treatment of XDR and MDR tuberculosis

被引：13

作者：

Bakal, Ravi L. ^{[1
]}

Gattani, Surendra G. ^{[2
]}

机构：

[1] Wadhwani Coll Pharm, Dept Med Chem, Yavatmal 445001, Maharashtra, India

[2] HR Patel Inst Pharmaceut Educ & Res, Dhule 425405, Maharashtra, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2012年 / 47卷

关键词：

MDR-TB; Mycobacterium tuberculosis; Oxadiazole; Clinical isolates; MULTIDRUG-RESISTANT TUBERCULOSIS; MYCOBACTERIUM-TUBERCULOSIS;

D O I：

10.1016/j.ejmech.2011.10.054

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Tuberculosis, the infection on the verge of eradication once, is now a great threat to mankind. Emergence of MDR and XDR-TB synergised with HIV and other immune-compressive diseases have increased the life threatening capacities of the disease. A small molecule has been identified here, which showed potent anti-tubercular activity. The identified hit compound has also been proved active against nearly 25 clinical isolates comparable with isoniazid. (C) 2011 Elsevier Masson SAS. All rights reserved.

引用

页码：278 / 282

页数：5

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