Association between physical activity and risk of hepatobiliary cancers: A multinational cohort study

被引：78

作者：

Baumeister, Sebastian E. ^{[1
,2
]}

Schlesinger, Sabrina ^{[3
]}

Aleksandrova, Krasimira ^{[4
]}

Jochem, Carmen ^{[5
]}

Jenab, Mazda ^{[6
]}

Gunter, Marc J. ^{[6
]}

Overvad, Kim ^{[7
]}

Tjonneland, Anne ^{[8
,9
]}

Boutron-Ruault, Marie-Christine ^{[10
,11
]}

Carbonnel, Franck ^{[10
,11
,12
]}

Fournier, Agnes ^{[10
,11
]}

Kuehn, Tilman ^{[13
]}

Kaaks, Rudolf ^{[13
]}

Pischon, Tobias ^{[14
]}

Boeing, Heiner ^{[4
]}

Trichopoulou, Antonia ^{[15
,16
]}

Bamia, Christina ^{[15
,16
]}

La Vecchia, Carlo ^{[15
,17
]}

Masala, Giovanna ^{[18
]}

Panico, Salvatore ^{[19
]}

Fasanelli, Francesca ^{[20
]}

Tumino, Rosario ^{[21
,22
]}

Grioni, Sara ^{[23
]}

de Mesquita, Bas Bueno ^{[24
]}

Vermeulen, Roel ^{[25
,26
]}

May, Anne M. ^{[27
]}

Borch, Kristin B. ^{[28
]}

Oyeyemi, Sunday O. ^{[28
]}

Ardanaz, Eva ^{[29
,30
,31
]}

Rodriguez-Barranco, Miguel ^{[31
,32
,33
]}

Chirlaque Lopez, Maria Dolores ^{[31
,34
]}

Felez-Nobrega, Mireia ^{[35
]}

Sonestedt, Emily ^{[36
]}

Ohlsson, Bodil ^{[37
]}

Hemmingsson, Oskar ^{[38
]}

Werner, Marten ^{[39
]}

Perez-Cornago, Aurora ^{[40
,41
]}

Ferrari, Pietro ^{[6
]}

Stepien, Magdalena ^{[6
]}

Freisling, Heinz ^{[6
]}

Tsilidis, Konstantinos K. ^{[40
,41
]}

Ward, Heather ^{[42
]}

Riboli, Elio ^{[42
]}

Weiderpass, Elisabete ^{[28
,43
,44
,45
,46
]}

Leitzmann, Michael F. ^{[5
]}

机构：

[1] Ludwig Maximilians Univ Munchen, UNIKA T Augsburg, Neusasser Str 47, D-86156 Augsburg, Germany

[2] Univ Med Greifswald, Inst Community Med, Greifswald, Germany

[3] Heinrich Heine Univ, Leibniz Ctr Diabet Res, German Diabet Ctr, Jr Res Grp Systemat Reviews,Inst Biometr & Epidem, Dusseldorf, Germany

[4] German Inst Human Nutr Potsdam Rehbrucke, Nuthetal, Germany

[5] Univ Regensburg, Dept Epidemiol & Prevent Med, Regensburg, Germany

[6] Int Agcy Res Canc, Sect Nutr & Metab, Lyon, France

[7] Aarhus Univ, Dept Publ Hlth, Sect Epidemiol, Aarhus, Denmark

[8] Danish Canc Soc Res Ctr, Diet Genes & Environm, Copenhagen, Denmark

[9] Univ Copenhagen, Fac Hlth & Med Sci, Dept Publ Hlth, Copenhagen, Denmark

[10] Univ Paris Saclay, Univ Paris Sud, CESP Ctr Rech Epidemiol & Sante Populat, UVSQ,INSERM, Villejuif, France

[11] Inst Gustave Roussy, Villejuif, France

[12] Bicetre Univ Hosp, AP HP, Dept Gastroenterol, Le Kremlin Bicetre, France

[13] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[14] Helmholtz Assoc MDC, Max Delbruck Ctr Mol Med, Mol Epidemiol Res Grp, Berlin, Germany

[15] Hellen Hlth Fdn, Athens, Greece

[16] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Nutr & Hlth,Unit Nutr Epide, Athens, Greece

[17] Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy

[18] Inst Canc Res Prevent & Clin Network ISPRO, Canc Risk Factors & Life Style Epidemiol Unit, Florence, Italy

[19] Univ Naples Federico II, Dipartimento Med Clin & Chirurgia, Naples, Italy

[20] Univ Turin, Dept Med Sci, Canc Epidemiol Unit, Turin, Italy

[21] Civ MP Arezzo Hosp, Canc Registry, ASP Ragusa, Ragusa, Italy

[22] Civ MP Arezzo Hosp, Histopathol Dept, ASP Ragusa, Ragusa, Italy

[23] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Via Venezian, Milan, Italy

[24] Natl Inst Publ Hlth & Environm, Ctr Nutr Prevent & Hlth Serv, Bilthoven, Netherlands

[25] Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands

[26] Univ Med Ctr, Julius Ctr Publ Hlth Sci & Primary Care, Utrecht, Netherlands

[27] Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[28] Univ Tromso, Arctic Univ Norway, Fac Hlth Sci, Dept Community Med, Tromso, Norway

[29] Navarra Publ Hlth Inst, Pamplona, Spain

[30] Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain

[31] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain

[32] Inst Invest Biosanitaria Ibs, Escuela Andaluza Salud Publ, Granada, Spain

[33] Univ Granada, Hosp Univ Granada, Granada, Spain

[34] Murcia Univ, Reg Hlth Council, Dept Epidemiol, IMIB Arrixaca, Murcia, Spain

[35] Catalan Inst Oncol IDIBELL, Unit Nutr & Canc, Canc Epidemiol Res Program, Barcelona, Spain

[36] Lund Univ, Dept Clin Sci Malmo, Lund, Sweden

[37] Lund Univ, Skane Univ Hosp, Dept Internal Med, Malmo, Sweden

[38] Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden

[39] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[40] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[41] Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina, Greece

[42] Imperial Coll London, Dept Epidemiol & Biostat, London, England

[43] Canc Registry Norway, Dept Res, Inst Populat Based Canc Res, Oslo, Norway

[44] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[45] Univ Helsinki, Folkhalsan Res Ctr, Genet Epidemiol Grp, Helsinki, Finland

[46] Univ Helsinki, Fac Med, Helsinki, Finland

来源：

JOURNAL OF HEPATOLOGY | 2019年 / 70卷 / 05期

基金：

英国医学研究理事会;

关键词：

Hepatobiliary cancer; Hepatocellular carcinoma; Liver cancer; Physical activity; HEPATOCELLULAR-CARCINOMA; VALIDITY; QUESTIONNAIRE; MORTALITY; OBESITY; DISEASE; BURDEN;

D O I：

10.1016/j.jhep.2018.12.014

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background & Aims: To date, evidence on the association between physical activity and risk of hepatobiliary cancers has been inconclusive. Weexamined this association in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC). Methods: We identified 275 hepatocellular carcinoma (HCC) cases, 93 intrahepatic bile duct cancers (IHBCs), and 164 non-gallbladder extrahepatic bile duct cancers (NGBCs) among 467,336 EPIC participants (median follow-up 14.9 years). We estimated cause-specific hazard ratios (HRs) for total physical activity and vigorous physical activity and performed mediation analysis and secondary analyses to assess robustness to confounding (e.g. due to hepatitis virus infection). Results: In the EPIC cohort, the multivariable-adjusted HR of HCC was 0.55 (95% CI 0.38-0.80) comparing active and inactive individuals. Regarding vigorous physical activity, for those reporting >2 hours/week compared to those with no vigorous activity, the HR for HCC was 0.50 (95% CI 0.33-0.76). Estimates were similar in sensitivity analyses for confounding. Total and vigorous physical activity were unrelated to IHBC and NGBC. In mediation analysis, waist circumference explained about 40% and body mass index 30% of the overall association of total physical activity and HCC. Conclusions: These findings suggest an inverse association between physical activity and risk of HCC, which is potentially mediated by obesity. Lay summary: In a pan-European study of 467,336 men and women, we found that physical activity is associated with a reduced risk of developing liver cancers over the next decade. This risk was independent of other liver cancer risk factors, and did not vary by age, gender, smoking status, body weight, and alcohol consumption. (C) 2019 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

引用

页码：885 / 892

页数：8

共 39 条

[1] The Burden of Primary Liver Cancer and Underlying Etiologies From 1990 to 2015 at the Global, Regional, and National Level Results From the Global Burden of Disease Study 2015 [J].

Akinyemiju, Tomi ;

Abera, Semaw ;

Ahmed, Muktar ;

Alam, Noore ;

Alemayohu, Mulubirhan Assefa ;

Allen, Christine ;

Al-Raddadi, Rajaa ;

Alvis-Guzman, Nelson ;

Amoako, Yaw ;

Artaman, Al ;

Ayele, Tadesse Awoke ;

Barac, Aleksandra ;

Bensenor, Isabela ;

Berhane, Adugnaw ;

Bhutta, Zulfiqar ;

Castillo-Rivas, Jacqueline ;

Chitheer, Abdulaal ;

Choi, Jee-Young ;

Cowie, Benjamin ;

Dandona, Lalit ;

Dandona, Rakhi ;

Dey, Subhojit ;

Dicker, Daniel ;

Phuc, Huyen ;

Ekwueme, Donatus U. ;

Zaki, Maysaa El Sayed ;

Fischer, Florian ;

Furst, Thomas ;

Hancock, Jamie ;

Hay, Simon I. ;

Hotez, Peter ;

Jee, Sun Ha ;

Kasaeian, Amir ;

Khader, Yousef ;

Khang, Young-Ho ;

Kumar, G. Anil ;

Kutz, Michael ;

Larson, Heidi ;

Lopez, Alan ;

Lunevicius, Raimundas ;

Malekzadeh, Reza ;

McAlinden, Colm ;

Meier, Toni ;

Mendoza, Walter ;

Mokdad, Ali ;

Moradi-Lakeh, Maziar ;

Nagel, Gabriele ;

Nguyen, Quyen ;

Nguyen, Grant ;

Ogbo, Felix .

JAMA ONCOLOGY, 2017, 3 (12) :1683-1691

[2]

Aleksandrova K, 2016, RECENT RESULTS CANC, V208, P177, DOI 10.1007/978-3-319-42542-9_10

[3] Physical activity across the lifespan and liver cancer incidence in the NIH-AARP Diet and Health Study cohort [J].

Arem, Hannah ;

Loftfield, Erikka ;

Saint-Maurice, Pedro F. ;

Freedman, Neal D. ;

Matthews, Charles E. .

CANCER MEDICINE, 2018, 7 (04) :1450-1457

[4] Multiple imputation of covariates by fully conditional specification: Accommodating the substantive model [J].

Bartlett, Jonathan W. ;

Seaman, Shaun R. ;

White, Ian R. ;

Carpenter, James R. .

STATISTICAL METHODS IN MEDICAL RESEARCH, 2015, 24 (04) :462-487

[5] The association between frequency of vigorous physical activity and hepatobiliary cancers in the NIH-AARP Diet and Health Study [J].

Behrens, Gundula ;

Matthews, Charles E. ;

Moore, Steven C. ;

Freedman, Neal D. ;

McGlynn, Katherine A. ;

Everhart, James E. ;

Hollenbeck, Albert R. ;

Leitzmann, Michael F. .

EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2013, 28 (01) :55-66

[6]

Benjaminsen Borch K, 2015, UPDATE TREAT PHYS AC

[7] Physical Activity and Liver Diseases [J].

Berzigotti, Annalisa ;

Saran, Uttara ;

Dufour, Jean-Francois .

HEPATOLOGY, 2016, 63 (03) :1026-1040

[8] The burden of liver disease in Europe: A review of available epidemiological data [J].

Blachier, Martin ;

Leleu, Henri ;

Peck-Radosavljevic, Markus ;

Valla, Dominique-Charles ;

Roudot-Thoraval, Francoise .

JOURNAL OF HEPATOLOGY, 2013, 58 (03) :593-608

[9] Criterion validity of a 10-category scale for ranking physical activity in Norwegian women [J].

Borch, Kristin B. ;

Ekelund, Ulf ;

Brage, Soren ;

Lund, Eiliv .

INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY, 2012, 9

[10] Comparison of hepatocellular carcinoma in Eastern versus Western populations [J].

Choo, Su Pin ;

Tan, Wan Ling ;

Goh, Brian K. P. ;

Tai, Wai Meng ;

Zhu, Andrew X. .

CANCER, 2016, 122 (22) :3430-3446

← 1 2 3 4 →