NONINVASIVE PRENATAL TESTING: THE ASPECTS OF ITS INTRODUCTION INTO CLINICAL PRACTICE

被引：0

作者：

Korostin, D. O. ^{[1
,2
]}

Plakhina, D. A. ^{[2
]}

Belova, V. A. ^{[1
,2
]}

机构：

[1] Pirogov Russian Natl Res Med Univ, Moscow, Russia

[2] Genotek Ltd, Moscow, Russia

来源：

BULLETIN OF RUSSIAN STATE MEDICAL UNIVERSITY | 2019年 / 03期

关键词：

NIPT; NIPS; prenatal screening; fetal aneuploidy; cell-free DNA; CELL-FREE DNA; FREE FETAL DNA; MATERNAL PLASMA DNA; POSITION STATEMENT; MEDICAL GENETICS; AMERICAN-COLLEGE; HUMAN ANEUPLOIDY; CHROMOSOMES; 13; TRISOMIES; 21; DIAGNOSIS;

D O I：

10.24075/brsmu.2019.036

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The last couple of years have witnessed the rapid development of prenatal molecular-based screening for fetal aneuploidies that utilizes the analysis of cell-free DNA circulating in the bloodstream of a pregnant woman. The present review looks at the potential and limitations of such testing and the possible causes of false-positive and false-negative results. The review also describes the underlying principles of data acquisition and analysis the testing involves. In addition, we talk about the opinions held by the expert community and some aspects of legislation on the use of noninvasive prenatal testing (NIPT) in clinical practice in the countries where NIPT is much more widespread than in Russia.

引用

页码：5 / 15

页数：11

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