Relationship between plasma high-mobility group box-1 levels and clinical outcomes of ischemic stroke

被引：39

作者：

Huang, Ju-Ming ^{[1
]}

Hu, Jin ^{[1
]}

Chen, Ning ^{[1
]}

Hu, Min-Lei ^{[1
]}

机构：

[1] First Hosp Jia Xing, Dept Neurol, Jiaxing 314001, Peoples R China

来源：

JOURNAL OF CRITICAL CARE | 2013年 / 28卷 / 05期

关键词：

Ischemic stroke; High mobility group box-1; Outcome; CHROMATIN PROTEIN HMGB1; GLYCATION END-PRODUCTS; SUBARACHNOID HEMORRHAGE; BRAIN; ACTIVATION; CYTOKINE; MEDIATOR; RECEPTOR; RELEASE; CELLS;

D O I：

10.1016/j.jcrc.2012.10.003

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Purpose: High-mobility group box-1 (HMGB1) is regarded as a central mediator of inflammation and involved in many inflammatory diseases. This study aimed to investigate impact of plasma HMGB1 level on 1-year clinical outcomes of ischemic stroke. Methods: Plasma HMGB1 levels of 338 patients were quantified by enzyme-linked immunosorbent assay. The end points were mortality and unfavorable outcome (modified Rankin Scale score>2) after 1 year. Results: Plasma HMGB1 level emerged as an independent predictor of 1-year clinical outcomes. Its prognostic value was similar to National Institutes of Health Stroke Scale score's. It improved prognostic value of National Institutes of Health Stroke Scale score. Conclusion: Plasma HMGB1 level represents a novel biomarker for predicting 1-year clinical outcomes of ischemic stroke. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：792 / 797

页数：6

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