One Dose of Tranexamic Acid Is Safe and Effective in Revision Knee Arthroplasty

被引：34
作者：
Smit, Kevin M. [1 ]
Naudie, Douglas D. R. [1 ]
Ralley, Fiona E. [2 ]
Berta, Donna M. [3 ]
Howard, James L. [1 ]
机构：
[1] Univ Western Ontario, London Hlth Sci Ctr, Div Orthopaed Surg, London, ON N6A 5A5, Canada
[2] Univ Western Ontario, London Hlth Sci Ctr, Dept Anesthesia & Perioperat Med, London, ON N6A 5A5, Canada
[3] London Hlth Sci Ctr, Ontario Transfus Coordinator ONTraC, London, ON, Canada
来源：
JOURNAL OF ARTHROPLASTY | 2013年 / 28卷 / 08期
关键词：
tranexamic acid; revision knee arthroplasty; blood loss;
D O I：
10.1016/j.arth.2013.05.036
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
Revision total knee arthroplasty (TKA) has been associated with an increased risk of perioperative blood loss. Tranexamic acid (TXA) has been proven to be safe and effective in preventing blood loss in primary TKA. The purpose of this study was to evaluate the effect of TXA on blood loss and transfusion rates in revision TKA. We performed a retrospective comparative study on 424 patients who had undergone revision TKA between January 2006 and March 2010. A total of 178 patients did not receive TXA while 246 patients received one intraoperative dose of 20 mg/kg of TXA given prior to tourniquet release. There was a significant reduction in hemoglobin loss (42 +/- 16 g/L vs 38 +/- 15 g/L, P = 0.005), transfusion rates (30.3% vs 16.7%, P = 0.001) and average amount transfused (1.1 +/- 1.9 units vs 0.5 +/- 1.1 units, P = 0.001) in the TXA group. There was no significant difference in recorded major adverse events with the administration of TXA. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：112 / 115
页数：4
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