The fibrate-activated PPARα/p16INK4A pathway inhibits vascular smooth muscle cell proliferation and vascular occlusion

被引:1
作者
Gizard, F [1 ]
Staels, B [1 ]
机构
[1] Univ Lille 2, INSERM, U 545, Dept Atherosclerose,Inst Pasteur Lille, F-59019 Lille, France
来源
M S-MEDECINE SCIENCES | 2006年 / 22卷 / 04期
关键词
D O I
10.1051/medsci/2006224351
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
引用
收藏
页码:351 / 353
页数:3
相关论文
共 13 条
[1]  
Carmeliet P, 1997, CIRC RES, V81, P829
[2]   Vascular proliferation and atherosclerosis: New perspectives and therapeutic strategies [J].
Dzau, VJ ;
Braun-Dullaeus, RC ;
Sedding, DG .
NATURE MEDICINE, 2002, 8 (11) :1249-1256
[3]  
Froeschl M, 2004, Curr Drug Targets Cardiovasc Haematol Disord, V4, P103, DOI 10.2174/1568006043481293
[4]   PPARα inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a [J].
Gizard, F ;
Amant, C ;
Barbier, O ;
Bellosta, S ;
Robillard, R ;
Percevault, F ;
Sevestre, H ;
Krimpenfort, P ;
Corsini, A ;
Rochette, J ;
Glineur, C ;
Fruchart, JC ;
Torpier, G ;
Staels, B .
JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (11) :3228-3238
[5]   Arterial smooth muscle cell heterogeneity - Implications for atherosclerosis and restenosis development [J].
Hao, HY ;
Gabbiani, G ;
Bochaton-Piallat, ML .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (09) :1510-1520
[6]   Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice [J].
Krimpenfort, P ;
Quon, KC ;
Mooi, WJ ;
Loonstra, A ;
Berns, A .
NATURE, 2001, 413 (6851) :83-86
[7]   CYCLINS, CYCLIN-DEPENDENT KINASES AND CDK INHIBITORS - IMPLICATIONS IN CELL-CYCLE CONTROL AND CANCER [J].
MACLACHLAN, TK ;
SANG, NL ;
GIORDANO, A .
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, 1995, 5 (02) :127-156
[8]   Peroxisome proliferator-activated receptors and atherogenesis - Regulators of gene expression in vascular cells [J].
Marx, N ;
Duez, H ;
Fruchart, JC ;
Staels, B .
CIRCULATION RESEARCH, 2004, 94 (09) :1168-1178
[9]   Peroxisome-proliferator-activated receptors and cancers: Complex stories [J].
Michalik, L ;
Desvergne, B ;
Wahli, W .
NATURE REVIEWS CANCER, 2004, 4 (01) :61-70
[10]   Relation of gemfibrozil treatment and lipid levels with major coronary events - VA-HIT: A randomized controlled trial [J].
Robins, SJ ;
Collins, D ;
Wittes, JT ;
Papademetriou, V ;
Deedwania, PC ;
Schaefer, EJ ;
McNamara, JR ;
Kashyap, ML ;
Hershman, JM ;
Wexler, LF ;
Rubins, HB .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (12) :1585-1591