New anti-malarial compounds from database searching

被引：22

作者：

Griffith, R ^{[1
]}

Chanphen, R

Leach, SP

Keller, PA

机构：

[1] Univ Newcastle, Sch Biol & Chem Sci, Newcastle, NSW 2308, Australia

[2] Univ Wollongong, Dept Chem, Wollongong, NSW 2522, Australia

[3] NSTDA, BIOTEC, Natl Ctr Genet Engn & Biotechnol, Bangkok 10400, Thailand

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(01)00811-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In a serendipitous result, pharmacophores generated for the database searching for new non-nucleoside inhibitors of the HIV-1 reverse transcriptase enzyme unearthed 12 new lead compounds which were active against the Plasmodium falciparum strain of malaria. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：539 / 542

页数：4