Wnt-4 potently inhibits capillary outgrowth from rat aorta in 3D culture

被引：3

作者：

Jover, Bernard ^{[1
]}

Girardot, Daphne ^{[1
]}

de Vacquieres, Francoise de Courtois Roy ^{[1
]}

Casellas, Daniel ^{[1
]}

Moles, Jean-Pierre ^{[2
]}

机构：

[1] Inst Univ Rech Clin, CNRS, Grp Rein & Hypertens, FRE3400, F-34093 Montpellier 5, France

[2] Univ Montpellier I, CHU Montpellier, INSERM, U1058, F-34000 Montpellier, France

来源：

FUNDAMENTAL & CLINICAL PHARMACOLOGY | 2013年 / 27卷 / 05期

关键词：

endothelial cells; retroviral infection; three-dimensional tissue culture; ENDOTHELIAL-CELLS; SIGNALING PATHWAYS; ANGIOGENESIS; PROLIFERATION; GROWTH; MODEL;

D O I：

10.1111/j.1472-8206.2012.01044.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Regulation of angiogenesis involves tight cell-to-cell and cell-to-extracellular-matrix interactions. Various reports demonstrate that the Wnt signaling pathways participate in this regulation. Using a three-dimensional aortic ring culture combined with an ex vivo retroviral infection approach, we evaluated the effects of two Wnt growth factors, Wnt-1 and Wnt-4, on the formation and growth of new capillaries. Our results show that Wnt-1 had no effect, whereas Wnt-4 was a potent inhibitor of capillary outgrowth in vitro.

引用

页码：465 / 470

页数：6

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