Results from the International Consensus Conference on myo-inositol and D-chiro-inositol in Obstetrics and Gynecology - assisted reproduction technology

被引：57

作者：

Bevilacqua, Arturo ^{[1
]}

Carlomagno, Gianfranco ^{[2
]}

Gerli, Sandro ^{[3
]}

Oliva, Mario Montanino ^{[4
]}

Devroey, Paul ^{[5
]}

Lanzone, Antonio ^{[6
]}

Soulange, Christophe ^{[7
]}

Facchinetti, Fabio ^{[8
]}

Di Renzo, Gian Carlo ^{[3
,9
]}

Bizzarri, Mariano ^{[10
]}

Hod, Moshe ^{[11
]}

Cavalli, Pietro ^{[12
]}

D'Anna, Rosario ^{[13
]}

Benvenga, Salvatore ^{[14
]}

Chiu, Tony T. ^{[15
]}

Kamenov, Zdravko A. ^{[16
]}

机构：

[1] Univ Roma La Sapienza, Dept Psychol, I-00185 Rome, Italy

[2] Lo Li Pharma R&D Dept, Rome, Italy

[3] Univ Perugia, Dept Obstet & Gynecol, I-06100 Perugia, Italy

[4] Clin Villa Mafalda, Ctr Reprod Med Res, Rome, Italy

[5] Dutch Speaking Free Univ Brussels, Ctr Reprod Med, Brussels, Belgium

[6] Univ Cattolica Sacro Cuore, Inst Obstet & Gynecol, I-00168 Rome, Italy

[7] Univ Lyon, INSERM U1060, CarMeN, INSA Lyon, Villeurbanne, France

[8] Univ Modena & Reggio Emilia, Mother Infant Dept, Modena, Italy

[9] PREIS Sch, Milan, Italy

[10] Univ Roma La Sapienza, Dept Expt Med, I-00185 Rome, Italy

[11] Helen Schneider Hosp Women, Rabin Med Ctr, Petah Tiqwa, Israel

[12] Ist Osped Cremona, Serv Genet, Cremona, Italy

[13] Univ Messina, Dept Obstet & Gynecol Sci, Messina, Italy

[14] Univ Messina, Dept Clin & Expt Med, Messina, Italy

[15] Hong Kong Reprod Med Ctr, Hong Kong, Hong Kong, Peoples R China

[16] Med Univ, Alexandrovska Univ Hosp, Clin Endocrinol, Sofia, Bulgaria

来源：

GYNECOLOGICAL ENDOCRINOLOGY | 2015年 / 31卷 / 06期

关键词：

Infertility; polycystic ovary syndrome; pregnancy; ovary; ovulation induction; POLYCYSTIC-OVARY-SYNDROME; IN-VITRO FERTILIZATION; SPERM MITOCHONDRIAL-FUNCTION; IMPROVE OOCYTE QUALITY; FOLLICULAR-FLUID; INJECTION CYCLES; COMBINED THERAPY; PLUS MELATONIN; POOR OOCYTE; WOMEN;

D O I：

10.3109/09513590.2015.1006616

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A substantial body of research on mammalian gametogenesis and human reproduction has recently investigated the effect of myo-inositol (Myolns) on oocyte and sperm cell quality, due to its possible application to medically assisted reproduction. With a growing number of both clinical and basic research papers, the meaning of several observations now needs to be interpreted under a solid and rigorous physiological framework. The 2013 Florence International Consensus Conference on Myo- and D-chiro-inositol in obstetrics and gynecology has answered a number of research questions concerning the use of the two stereoisomers in assisted reproductive technologies. Available clinical trials and studies on the physiological and pharmacological effects of these molecules have been surveyed. Specifically, the physiological involvement of Myolns in oocyte maturation and sperm cell functions has been discussed, providing an answer to the following questions: (1) Are inositols physiologically involved in oocyte maturation? (2) Are inositols involved in the physiology of spermatozoa function? (3) Is treatment with inositols helpful within assisted reproduction technology cycles? (4) Are there any differences in clinical efficacy between Myolns and D-chiro-inositol? The conclusions of this Conference, drawn depending on expert panel opinions and shared with all the participants, are summarized in this review paper.

引用

页码：441 / 446

页数：6

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