Interactions between inflammation and lipid metabolism: Relevance for efficacy of anti-inflammatory drugs in the treatment of atherosclerosis

被引：239
作者：
van Diepen, Janna A. [1 ,2 ,6 ]
Berbee, Jimmy F. P. [1 ,3 ,6 ]
Havekes, Louis M. [1 ,4 ,5 ,6 ]
Rensen, Patrick C. N. [1 ,6 ]
机构：
[1] Leiden Univ, Med Ctr, Dept Gen Internal Med Endocrinol & Metab Dis, NL-2300 RC Leiden, Netherlands
[2] Radboud Univ Nijmegen, Med Ctr, Dept Gen Internal Med, NL-6525 ED Nijmegen, Netherlands
[3] Univ Patras, Sch Med, Dept Med, Rion, Greece
[4] Leiden Univ, Med Ctr, Dept Cardiol, NL-2300 RC Leiden, Netherlands
[5] TNO Qual Life, Gaubius Lab, Dept Biomed Res, NL-2301 CE Leiden, Netherlands
[6] Leiden Univ, Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands
来源：
ATHEROSCLEROSIS | 2013年 / 228卷 / 02期
关键词：
Inflammation; Fatty acids; Inflammation-lowering drugs; Lipoproteins; Mouse models; Lipid metabolism; Atherosclerosis; INTERLEUKIN-1 RECEPTOR ANTAGONIST; HIGH-DENSITY-LIPOPROTEIN; C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA; LIVER X RECEPTORS; FACTOR-KAPPA-B; RHEUMATOID-ARTHRITIS; FATTY-ACIDS; HEPATIC LIPOGENESIS; DIETARY-CHOLESTEROL;
D O I：
10.1016/j.atherosclerosis.2013.02.028
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Dyslipidemia and inflammation are well known causal risk factors the development of atherosclerosis. The interplay between lipid metabolism and inflammation at multiple levels in metabolic active tissues may exacerbate the development of atherosclerosis, and will be discussed in this review. Cholesterol, fatty acids and modified lipids can directly activate inflammatory pathways. In addition, circulating (modified) lipoproteins modulate the activity of leukocytes. Vice versa, proinflammatory signaling (i.e. cytokines) in pre-clinical models directly affects lipid metabolism. Whereas the main lipid-lowering drugs all have potent anti-inflammatory actions, the lipid-modulating actions of anti-inflammatory agents appear to be less straightforward. The latter have mainly been evaluated in pre-clinical models and in patients with chronic inflammatory diseases, which will be discussed. The clinical trials that are currently conducted to evaluate the efficacy of anti-inflammatory agents in the treatment of cardiovascular diseases may additionally reveal potential (beneficial) effects of these therapeutics on lipid metabolism in the general population at risk for CVD. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：306 / 315
页数：10
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