In vitro release studies of vitamin B12 from poly N-vinyl pyrrolidone/starch hydrogels grafted with acrylic acid synthesized by gamma radiation

被引:33
作者
Eid, M. [1 ]
机构
[1] Natl Ctr Radiat Res & Technol, Nasr City 11731, Cairo, Egypt
关键词
Hydrogel; N-Vinyl-2-pyrrolidone; Starch; Swelling; Vitamin B-12; Drug release;
D O I
10.1016/j.nimb.2008.09.003
中图分类号
TH7 [仪器、仪表];
学科分类号
0804 ; 080401 ; 081102 ;
摘要
Co-polymeric hydrogels containing N-vinyl pyrrolidone and starch grafted with acrylic acid were synthesized by gamma radiation to be used as drug delivery system. Their gel contents, grafting swelling and thermal gravinnetric analysis were evaluated. The gel content increases by increasing the irradiation dose up to 50 kGy, then decreases. The grafting percent increases by the increasing of acrylic acid. The thermal stability and the rate of the thermal decomposition changed according to the different compositions. The maximum rate of the thermal decomposition decreases by increasing the irradiation dose from 20 to 30 kGy and increases by increasing the irradiation dose from 30 to 70 kGy. The hydrogels loaded with vitamin B-12 demonstrated a decrease release in acidic medium than the neutral one. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:5020 / 5026
页数:7
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