Serum pigment epithelium-derived factor levels are independently correlated with the presence of coronary artery disease

被引：27

作者：

Wang, Feifei ^{[1
]}

Ma, Xiaojing ^{[1
]}

Zhou, Mi ^{[1
]}

Pan, Xiaoping ^{[1
]}

Ni, Jie ^{[1
]}

Gao, Meifang ^{[2
]}

Lu, Zhigang ^{[2
]}

Hang, Jingyu ^{[2
]}

Bao, Yuqian ^{[1
]}

Jia, Weiping ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Diabet Inst,Affiliated Peoples Hosp 6, Dept Endocrinol & Metab,Shanghai Clin Ctr Diabet, Shanghai Key Clin Ctr Metab Dis,Shanghai Key Lab, Shanghai 200030, Peoples R China

[2] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Cardiol, Shanghai 200030, Peoples R China

来源：

CARDIOVASCULAR DIABETOLOGY | 2013年 / 12卷

基金：

中国国家自然科学基金;

关键词：

Atherosclerosis; Coronary angiography; Coronary artery disease; Metabolic syndrome; Pigment epithelium-derived factor; METABOLIC SYNDROME; FACTOR PEDF; RISK; DIFFERENTIATION; PROTEIN; EVENTS; MARKER; RATS;

D O I：

10.1186/1475-2840-12-56

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Pigment epithelium-derived factor (PEDF) has been proved to be closely correlated with metabolic syndrome (MetS) and its components that are all risk factors of cardiovascular disease and may play a protective role against vascular injury and atherosclerosis. The present study was designed to investigate the relationship between serum PEDF and coronary artery disease (CAD). Methods: A total of 312 consecutive in-patients (including 228 with CAD and 197 with MetS) who underwent coronary angiography were enrolled. Serum PEDF was measured by sandwich enzyme immunoassay and used to carry out multivariate stepwise regression analysis to assess correlation with patient demographic and clinical parameters. Multiple logistic regression analysis was performed to identify factors independently correlated with CAD. Results: Patients with MetS had significantly higher levels of serum PEDF than non-MetS subjects (11.1(8.2, 14.2) vs. 10.1 (7.6, 12.4) mu g/mL; P < 0.05). Patients with CAD also had significantly higher serum PEDF than non-CAD subjects (11.0(8.1, 14.2) vs. 10.3(8.1, 12.8) mu g/mL; P < 0.05). Triglyceride (TG), C-reactive protein (CRP), estimated glomerular filtration rate (eGFR), and hypoglycemic therapy were independently correlated with serum PEDF levels, and serum PEDF was independently positively correlated with CAD. Conclusions: Serum PEDF levels are independently positively associated with CAD in a Chinese population. Elevated PEDF may act as a protective response against vascular damage and subsequent CAD.

引用

页数：8