Cryogel biocomposite containing chitosan-gelatin/cerium-zinc doped hydroxyapatite for bone tissue engineering

被引：24
作者：
Wu, Shiqing [1 ]
Ma, Shengzhong [1 ]
Zhang, Cheng [1 ]
Cao, Guangqing [1 ]
Wu, Dongjin [1 ]
Gao, Chunzheng [1 ]
Lakshmanan, Sivalingam [2 ]
机构：
[1] Shandong Univ, Dept Spinal Surg, Hosp 2, 247 Beiyuan Rd, Jinan 250033, Shandong, Peoples R China
[2] Bharath Univ, Dept Chem, BIHER, Chennai 600073, Tamil Nadu, India
来源：
SAUDI JOURNAL OF BIOLOGICAL SCIENCES | 2020年 / 27卷 / 10期
关键词：
Antibacterial activity; Cryogel; Biocomposite; Bone; Chitosan; Hydroxyapatite; SCAFFOLDS; COATINGS; SURFACES;
D O I：
10.1016/j.sjbs.2020.05.045
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The present examination includes manufacture and portrayal of cryogel bio-composite implants containing chitosan-gelatin (CS-GT), cerium-zinc doped hydroxyapatite (CS-GT/Ce-Zn-HA) by cryogelation technique. The prepared cryogel biocomposites (CS-GT/HA and CS-GT/Ce-Zn-HA) were described by scanning electron microscope (SEM) and X-Ray diffraction (XRD) contemplates. The expansion of Ce-Zn in the CS-GT implants essentially expanded growing, diminished swelling, expanded protein sorption, and expanded bactericidal movement. The CS-GT/Ce-Zn-HA biocomposite had non-toxic towards rodent osteoblast cells. So the created CS-GT/Ce-Zn-HA biocomposite has favorable and potential applications over the CS-GT/HA platforms for bone tissue engineering. (C) 2020 The Authors. Published by Elsevier B.V. on behalf of King Saud University.
引用
收藏
页码：2638 / 2644
页数：7
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