Facilitating the Analysis of Immunological Data with Visual Analytic Techniques

被引:6
|
作者
Shih, David C. [1 ,2 ]
Ho, Kevin C. [1 ]
Melnick, Kyle M. [3 ]
Rensink, Ronald A. [2 ,3 ]
Kollmann, Tobias R. [1 ]
Fortuno, Edgardo S. [1 ]
机构
[1] Univ British Columbia, Child & Family Res Inst, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 1M9, Canada
[2] Univ British Columbia, Dept Comp Sci, Vancouver, BC V5Z 1M9, Canada
[3] Univ British Columbia, Dept Psychol, Vancouver, BC V5Z 1M9, Canada
来源
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS | 2011年 / 47期
关键词
Immunology; Issue; 47; Visual analytics; flow cytometry; Luminex; Tableau; cytokine; innate immunity; single nucleotide polymorphism;
D O I
10.3791/2397
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Visual analytics (VA) has emerged as a new way to analyze large dataset through interactive visual display. We demonstrated the utility and the flexibility of a VA approach in the analysis of biological datasets. Examples of these datasets in immunology include flow cytometry, Luminex data, and genotyping (e.g., single nucleotide polymorphism) data. Contrary to the traditional information visualization approach, VA restores the analysis power in the hands of analyst by allowing the analyst to engage in real-time data exploration process. We selected the VA software called Tableau after evaluating several VA tools. Two types of analysis tasks analysis within and between datasets were demonstrated in the video presentation using an approach called paired analysis. Paired analysis, as defined in VA, is an analysis approach in which a VA tool expert works side-by-side with a domain expert during the analysis. The domain expert is the one who understands the significance of the data, and asks the questions that the collected data might address. The tool expert then creates visualizations to help find patterns in the data that might answer these questions. The short lag-time between the hypothesis generation and the rapid visual display of the data is the main advantage of a VA approach.
引用
收藏
页数:6
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