Rhodium(III)-Catalyzed Oxidative C-H Coupling of N-Methoxybenzamides with Aryl Boronic Acids: One-Pot Synthesis of Phenanthridinones

被引：152
|
作者：
Karthikeyan, Jaganathan [1 ]
Haridharan, Radhakrishnan [1 ]
Cheng, Chien-Hong [1 ]
机构：
[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 49期
关键词：
C-H activation; cross-coupling; homogeneous catalysis; phenanthridinones; rhodium; CATALYZED DIRECT ARYLATION; CARBON-HYDROGEN BONDS; INTERNAL ALKYNES; ISOQUINOLINIUM SALTS; ARYLBORON REAGENTS; ROOM-TEMPERATURE; ACTIVATION; CLEAVAGE; FUNCTIONALIZATION; MULTIPLE;
D O I：
10.1002/anie.201206890
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
General solution: An efficient rhodium-catalyzed dual CiH bond activation and cyclization of N-methoxybenzamides 1 with aryl boronic acids 2 (see scheme; Cp=Me5C5) provides a straightforward and general approach to the phenanthridinone structure, which occurs widely in natural products and drugs. Highly regioselective CiC and CiN bond formation under mild conditions afforded a wide range of substituted phenanthridinones 3. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：12343 / 12347
页数：5
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