Rhodium(III)-Catalyzed Oxidative C-H Coupling of N-Methoxybenzamides with Aryl Boronic Acids: One-Pot Synthesis of Phenanthridinones

被引：152

作者：

Karthikeyan, Jaganathan ^{[1
]}

Haridharan, Radhakrishnan ^{[1
]}

Cheng, Chien-Hong ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 49期

关键词：

C-H activation; cross-coupling; homogeneous catalysis; phenanthridinones; rhodium; CATALYZED DIRECT ARYLATION; CARBON-HYDROGEN BONDS; INTERNAL ALKYNES; ISOQUINOLINIUM SALTS; ARYLBORON REAGENTS; ROOM-TEMPERATURE; ACTIVATION; CLEAVAGE; FUNCTIONALIZATION; MULTIPLE;

D O I：

10.1002/anie.201206890

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

General solution: An efficient rhodium-catalyzed dual CiH bond activation and cyclization of N-methoxybenzamides 1 with aryl boronic acids 2 (see scheme; Cp=Me5C5) provides a straightforward and general approach to the phenanthridinone structure, which occurs widely in natural products and drugs. Highly regioselective CiC and CiN bond formation under mild conditions afforded a wide range of substituted phenanthridinones 3. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：12343 / 12347

页数：5

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