Anterior Spinal Overgrowth of the Thoracic Spine May Not Be Involved in the Initiation of Adolescent Idiopathic Scoliosis

OBJECTIVE: To compare vertebral morphology among patients with adolescent idiopathic scoliosis (AIS), patients with Chiari I malformation (CMS)-associated scoliosis, and normal control subjects, with the goal of determining the role of anterior column overgrowth in the development of AIS. METHODS: One hundred and forty adolescent girls were enrolled (50 with AIS, 40 with CMS, and 50 control subjects). Thoracic computed tomography images were obtained for all subjects. Anterior height of the vertebral body (VBHa), posterior height of the vertebral body (VBHp), and height of the pedicle (PH) were measured for each level. Finally, the ratios of VBHa and VBHp to PH were calculated and compared among the 3 groups. RESULTS: Compared with the control group, both the AIS and CMS groups exhibited consistently longer VBHa and VBHp for most thoracic vertebral bodies, whereas the PH of most vertebral bodies was shorter in both AIS and CMS groups. Moreover, the ratios for differential growth between the anterior and posterior elements of each thoracic vertebra in both the AIS and CMS groups were significantly larger than the ratios in the control group. However, for all mentioned parameters, there were no significant differences between the AIS and CMS groups. CONCLUSIONS: Faster growth of the anterior spinal column was confirmed by longer vertebral bodies and shorter pedicles in both patient groups. Relative anterior spinal overgrowth of the thoracic spine is not involved in the initiation of AIS, and the abnormal growth pattern of the vertebral body in AIS might be a secondary change to the spinal curve.