Therapeutic Strategies for Alzheimer's and Parkinson's Diseases by Means of Drug Delivery Systems

被引：18

作者：

Cunha, S. ^{[1
,2
]}

Amaral, M. H. ^{[2
]}

Sousa Lobo, J. M. ^{[2
]}

Silva, A. C. ^{[1
,2
]}

机构：

[1] Fernando Pessoa Univ, Fac Hlth Sci, CEBIMED Biomed Res Ctr, UFP Energy Environm & Hlth Res Unit,FP ENAS, Rua Carlos Maia 296, P-4200150 Oporto, Portugal

[2] Univ Porto, Fac Pharm, Ctr Res Pharmaceut Sci, Lab Pharmaceut Technol, Rua Jorge Viterbo Ferreira 228, P-4050313 Oporto, Portugal

来源：

CURRENT MEDICINAL CHEMISTRY | 2016年 / 23卷 / 31期

关键词：

Alzheimer's disease; Parkinson's disease; Liposomes; Micelles; Nanoparticles; Exosomes; Dendrimers; Fullerenes; SOLID LIPID NANOPARTICLES; CENTRAL-NERVOUS-SYSTEM; MAGNETIC NANOPARTICLES; NEURODEGENERATIVE DISORDERS; POLYMERIC NANOPARTICLES; AMYLOID PLAQUES; BRAIN DELIVERY; GROWTH-FACTOR; CURCUMIN; ACID;

D O I：

10.2174/0929867323666160824162401

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alzheimer's and Parkinson's diseases are prevalent neurodegenerative disorders worldwide, which are essentially related to aging. Within the remarkable era of nanomedicine, nowadays several delivery systems have been suggested to improve the treatment of these disorders, namely, liposomes, micelles, nanoparticles (polymeric, lipid, metallic and inorganic), exosomes, dendrimers and fullerenes. The advantage that has been claimed to these delivery systems is that they facilitate the passage of drugs through the blood brain barrier (BBB), enabling targeting before body degradation, and increasing therapeutic efficacy, comparied to conventional pharmaceutical dosage forms. This review article provides a state of the art regarding the drug delivery systems that have been studied for the treatment of Alzheimer's and Parkinson's diseases. It begins with a brief description of the central nervous system (CNS) and the mechanisms involved in the development of these diseases. Later, some examples of drugs used in the treatment of these neurodegenerative diseases are presented, which are currently available in conventional pharmaceutical dosage forms, and in new drug delivery systems that are under development.

引用

页码：3618 / 3631

页数：14

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