No DREAM, no pain: Closing the spinal gate

被引：67
作者：
Costigan, M
Woolf, CJ [1 ]
机构：
[1] Massachusetts Gen Hosp, Dept Anesthesia & Crit Care, Neural Plast Res Grp, Charlestown, MA 02129 USA
[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp E, Charlestown, MA 02129 USA
来源：
CELL | 2002年 / 108卷 / 03期
关键词：
D O I：
10.1016/S0092-8674(02)00640-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pain transmission in the spinal cord is regulated by a balance of facilitatory and inhibitory influences operating on the neural circuits of the somatosensory system. The transcriptional repressor DREAM acts constitutively to suppress prodynorphin expression in spinal cord neurons. Knocking out DREAM results in sufficient dynorphin expression to produce a strong reduction in generalized pain behavior, highlighting the role that intracellular molecules play in modulating pain gating in the spinal cord.
引用
收藏
页码：297 / 300
页数：4
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