Atherosclerosis and proteinase activation

被引：182
作者：
Dollery, CM
Libby, P
机构：
[1] Ctr Cardiovasc Biol & Med, Div Med, Rayne Inst, London WC1E 6JJ, England
[2] Brigham & Womens Hosp, Leducq Transatlantic Network Excellence Atherothr, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Boston, MA 02115 USA
来源：
CARDIOVASCULAR RESEARCH | 2006年 / 69卷 / 03期
关键词：
atherosclerosis; metalloproteinase; plaque; matrix;
D O I：
10.1016/j.cardiores.2005.11.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Rapidly accumulating evidence points to the matrix metalloproteinases (MMPs) as major molecular mediators of arterial diseases. Findings from human pathological specimens, animals, and cell and molecular biology implicate matrix metalloproteinases in all stages of atherosclerosis including lesion initiation and progression and ultimately in plaque complication and triggering of thrombosis. The complex interactions within the proteolytic cascade allow multiple levels of control over these functions. This review weighs the evidence for the role of MMPs in arterial biology with particular reference to their activation in the atherosclerotic plaque. (c) 2005 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：625 / 635
页数：11
相关论文
共 122 条
[1]   Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma - A potential mechanism of lesion stabilization [J].
Aikawa, M ;
Rabkin, E ;
Okada, Y ;
Voglic, SJ ;
Clinton, SK ;
Brinckerhoff, CE ;
Sukhova, GK ;
Libby, P .
CIRCULATION, 1998, 97 (24) :2433-2444
[2]  
Aikawa M, 2001, CIRCULATION, V103, P276
[3]  
[Anonymous], 2005, EUROPEAN CARDIOVASCU
[4]  
[Anonymous], 2005, HEART DIS STROKE STA
[5]   Uniaxial strain upregulates matrix-degrading enzymes produced by human vascular smooth muscle cells [J].
Asanuma, K ;
Magid, R ;
Johnson, C ;
Nerem, RM ;
Galis, ZS .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2003, 284 (05) :H1778-H1784
[6]   Prospective, randomized, double-blind trial investigating the effect of doxycycline on matrix metalloproteinase expression within atherosclerotic carotid plaques [J].
Axisa, B ;
Loftus, IM ;
Naylor, AR ;
Goodall, S ;
Jones, L ;
Bell, PRF ;
Thompson, MM .
STROKE, 2002, 33 (12) :2858-2864
[7]   Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro - TIMP-3 promotes apoptosis [J].
Baker, AH ;
Zaltsman, AB ;
George, SJ ;
Newby, AC .
JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (06) :1478-1487
[8]   Involvement of PA/plasmin system in the processing of pro-MMP-9 and in the second step of pro-MMP-2 activation [J].
Baramova, EN ;
Bajou, K ;
Remacle, A ;
LHoir, C ;
Krell, HW ;
Weidle, UH ;
Noel, A ;
Foidart, JM .
FEBS LETTERS, 1997, 405 (02) :157-162
[9]   Focalized proteolysis: Spatial and temporal regulation of extracellular matrix degradation at the cell surface [J].
Basbaum, CB ;
Werb, Z .
CURRENT OPINION IN CELL BIOLOGY, 1996, 8 (05) :731-738
[10]   Prolonged administration of doxycycline in patients with small asymptomatic abdominal aortic aneurysms: Report of a prospective (Phase II) multicenter study [J].
Baxter, BT ;
Pearce, WH ;
Waltke, EA ;
Littooy, FN ;
Hallett, JW ;
Kent, KC ;
Upchurch, GR ;
Chaikof, EL ;
Mills, JL ;
Fleckten, B ;
Longo, GM ;
Lee, JK ;
Thompson, RW .
JOURNAL OF VASCULAR SURGERY, 2002, 36 (01) :1-12
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