Investigation of host factors possibly enhancing the emergence of the chondroitin sulfate A-binding phenotype in Plasmodium falciparum

被引：5

作者：

Nunes, Marta C. ^{[1
]}

Sterkers, Yvon ^{[1
]}

Gamain, Benoit ^{[1
]}

Scherf, Artur ^{[1
]}

机构：

[1] Inst Pasteur, Unite Biol Interact Hote Parasite, CNRS, URA 2581, F-75724 Paris 15, France

来源：

MICROBES AND INFECTION | 2008年 / 10卷 / 08期

关键词：

placental malaria; Plasmodium falciparum; var2CSA;

D O I：

10.1016/j.micinf.2008.05.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In malaria endemic areas, regardless of immunity acquired during lifelong exposure to malaria, pregnant women become susceptible to Plasmodium falciparum infections. Malaria during pregnancy is associated with a massive sequestration of infected erythrocytes in the placenta and the emergence of a unique parasite-derived adhesive molecule (encoded by var2CSA) that binds to chondroitin sulfate A (CSA). How P. falciparum achieves the timely expression of the CSA ligand in pregnant women remains puzzling. We investigated whether host serum-specific factors present only during pregnancy may induce var2CSA expression. Our panel of experiments did not reveal significant changes in var2CSA levels and CSA-binding capacity. (c) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：928 / 932

页数：5

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