Decreased plasma nociceptin/orphanin FQ levels after acute coronary syndromes

被引：5

作者：

Csobay-Novak, Cs ^{[2
]}

Sotonyi, P. ^{[3
]}

Krepuska, M. ^{[3
]}

Zima, E. ^{[2
]}

Szilagyi, N. ^{[4
]}

Toth, Sz ^{[5
]}

Szeberin, Z. ^{[3
]}

Acsady, Gy ^{[3
]}

Merkely, B. ^{[2
]}

Tekes, K. ^{[1
]}

机构：

[1] Semmelweis Univ, Fac Pharm, Dept Pharmacodynam, H-1089 Budapest, Hungary

[2] Semmelweis Univ, Fac Med, Ctr Heart, H-1089 Budapest, Hungary

[3] Semmelweis Univ, Fac Med, Dept Vasc Surg, H-1089 Budapest, Hungary

[4] Eotvos Lorand Univ Sci, Inst Biol, Dept Physiol & Neurobiol, Budapest, Hungary

[5] Semmelweis Univ, Fac Med, Dept Transplantat & Surg, H-1089 Budapest, Hungary

来源：

ACTA PHYSIOLOGICA HUNGARICA | 2012年 / 99卷 / 02期

关键词：

acute coronary syndrome; angina pectoris; nociceptin/orphanin FQ; ischemic stress; MYOCARDIAL-ISCHEMIA; ORPHANIN-FQ; RECEPTOR; RAT; EXPRESSION; NEURONS; CLONING; FAMILY; MEMBER; BLOOD;

D O I：

10.1556/APhysiol.99.2012.2.2

中图分类号：

学科分类号：

摘要：

Foregoing researches made on the N/OFQ system brought up a possible role for this system in cardiovascular regulation. In this study we examined how N/OFQ levels of the blood plasma changed in acute cardiovascular diseases. Three cardiac patient groups were created: enzyme positive acute coronary syndrome (EPACS, n = 10), enzyme negative ACS (ENACS, n = 7) and ischemic heart disease (IHD, n = 11). We compared the patients to healthy control subjects (n = 31). We found significantly lower N/OFQ levels in the EPACS [6.86 (6.21-7.38) pg/ml], ENACS [6.97 (6.87-7.01) pg/ml and IHD groups [7.58 (7.23-8.20) pg/ml] compared to the control group [8.86 (7.27-9.83) pg/ml]. A significant correlation was detected between N/OFQ and white blood cell count (WBC), platelet count (PLT), creatine kinase (CK), glutamate oxaloacetate transaminase (GOT) and cholesterol levels in the EPACS group. Decreased plasma N/OFQ is closely associated with the presence of acute cardiovascular disease, and the severity of symptoms has a significant negative correlation with the N/OFQ levels. We believe that the rate of N/OFQ depression is in association with the level of ischemic stress and the following inflammatory response. Further investigations are needed to clarify the relevance and elucidate the exact effects of the ischemic stress on the N/OFQ system.

引用

页码：99 / 110

页数：12

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