Solid-phase synthesis of α,α-difluoro-β-amino acids via the Reformatsky reaction

被引:34
作者
Vidal, A [1 ]
Nefzi, A [1 ]
Houghten, RA [1 ]
机构
[1] Torrey Pines Inst Mol Studies, San Diego, CA 92121 USA
关键词
D O I
10.1021/jo010872z
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:8268 / 8272
页数:5
相关论文
共 39 条
[1]   GENERAL-SYNTHESIS OF POLYFUNCTIONALIZED FLUOROMETHYLENEKETONE RETROAMIDES AS POTENTIAL INHIBITORS OF THROMBIN [J].
ALTENBURGER, JM ;
SCHIRLIN, D .
TETRAHEDRON LETTERS, 1991, 32 (49) :7255-7258
[2]   SYNTHESIS OF A PEPTIDYL 2,2-DIFLUORO-3-AMINOPROPIONATE [J].
ANGELASTRO, MR ;
BEY, P ;
MEHDI, S ;
PEET, NP .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1992, 2 (10) :1235-1238
[3]  
[Anonymous], 1991, Fluorine in Bioorganic Chemistry
[4]   Residue-based control of helix shape in beta-peptide oligomers [J].
Appella, DH ;
Christianson, LA ;
Klein, DA ;
Powell, DR ;
Huang, XL ;
Barchi, JJ ;
Gellman, SH .
NATURE, 1997, 387 (6631) :381-384
[5]   PREPARATION OF TRIFLUOROMETHYL KETONES AND RELATED FLUORINATED KETONES [J].
BEGUE, JP ;
BONNETDELPON, D .
TETRAHEDRON, 1991, 47 (20-21) :3207-3258
[6]  
BORGMAN S, 1997, CHEM ENG NEWS 0616, P32
[7]  
BURTON DJ, 1995, ACS MONOGR SER, V187, P684
[8]   DESIGN AND SYNTHESIS OF POTENT, SELECTIVE, AND ORALLY ACTIVE FLUORINE-CONTAINING RENIN INHIBITORS [J].
DOHERTY, AM ;
SIRCAR, I ;
KORNBERG, BE ;
QUIN, J ;
WINTERS, RT ;
KALTENBRONN, JS ;
TAYLOR, MD ;
BATLEY, BL ;
RAPUNDALO, SR ;
RYAN, MJ ;
PAINCHAUD, CA .
JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (01) :2-14
[9]   Comprehensive survey of chemical libraries yielding enzyme inhibitors, receptor agonists and antagonists, and other biologically active agents: 1992 through 1997 [J].
Dolle, RE .
MOLECULAR DIVERSITY, 1998, 3 (04) :199-233
[10]   Comprehensive survey of combinatorial library synthesis: 1998 [J].
Dolle, RE ;
Nelson, KH .
JOURNAL OF COMBINATORIAL CHEMISTRY, 1999, 1 (04) :235-282