Accommodating fluorinated amino acids in a helical peptide environment

被引：20
|
作者：
Nyakatura, Elisabeth K. [1 ]
Reimann, Oliver [1 ]
Vagt, Toni [2 ]
Salwiczek, Mario [1 ]
Koksch, Beate [1 ]
机构：
[1] Free Univ Berlin, Inst Chem & Biochem Organ Chem, D-14195 Berlin, Germany
[2] ETH, Inst Mol Biol & Biophys, CH-8093 Zurich, Switzerland
来源：
RSC ADVANCES | 2013年 / 3卷 / 18期
关键词：
COILED-COILS; PHAGE DISPLAY; OLIGOMERIZATION STATE; BUNDLE PROTEIN; STABILITY; DESIGN; HEXAFLUOROLEUCINE; POSITION;
D O I：
10.1039/c3ra41110a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Fluorinated amino acids represent useful building blocks for structural and functional upgrading of peptides and proteins. Here, we report the identification of a suitable environment for fluorinated aminobutyric acids in a central d-position of a heterodimeric coiled-coil assembly via phage display.
引用
收藏
页码：6319 / 6322
页数：4
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