Synthesis and cytotoxicity evaluation of highly functionalized pyranochromenes and pyranopyrans

被引：47
作者：
Emmadi, Narender Reddy [1 ]
Atmakur, Krishnaiah [1 ]
Chityal, Ganesh Kumar [2 ]
Pombala, Sujitha [2 ]
Nanubolu, Jagadeesh Babu [3 ]
机构：
[1] Indian Inst Chem Technol, Crop Protect Chem Div, Hyderabad 500607, Andhra Pradesh, India
[2] Indian Inst Chem Technol, Biol Chem Lab, Hyderabad 500607, Andhra Pradesh, India
[3] Indian Inst Chem Technol, Lab Xray Crystallog, Hyderabad 500607, Andhra Pradesh, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 23期
关键词：
4-Hydroxy chromenes; Ethyltrifluoro acetoacetate; Aromatic aldehydes; Tetrahydropyrano[3,2-c]chromenes; Dihydropyrano[3,2-b]pyrans; DERIVATIVES; 2-AMINO-2-CHROMENES; CHEMISTRY; CATALYST;
D O I：
10.1016/j.bmcl.2012.09.018
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of fluorinated tetrahydropyrano[3,2-c]chromenes and dihydropyrano[3,2-b]pyran derivatives have been synthesized and their in vitro cytotoxic activities have been determined in cervical cancer cell line (HeLa), human breast adenocarcinoma cell line (MDA-MB-231 and MCF-7) and human alveolar adenocarcinoma cell line (A549). Compounds 4g, 4k, 4p showed a very potent activity against MDA-MB-231, and 4c, 4p showed promising activity against MCF-7, while compounds 4c, 4g, 4p showed moderate activity against HeLa. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7261 / 7264
页数：4
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