PELP1 protein and the estrogen non-genomic signaling pathway

Estrogen exerts its biological effects through two signal pathways, the genomic and non-genomic pathway, both of which contribute to cell homeostasis. The non-genomic pathway has been suggested to be important in estrogen-induced cardio-, neuron-, and osteoprotection, and confers the ability of the cell to rapidly respond to its environment. The effects of the non-genomic pathway are the regulation of different cellular processes, such as proliferation, survival, apoptosis, and other functions in diverse cell-types. The proline-, glutamic acid-, and leucine-rich protein 1 (PELP1), is now known as a modulator of the estrogen receptors, and is also a novel coregulator of the non-genomic signal pathway with various functions. Therefore, the evaluation of the molecular crosstalk between PELP1 and the non-genomic pathway may lead to the development of functionally selective estrogen receptor modulators which can participate in the multiple functions of estrogen signaling in reproductive tissues and other organs.