Multi-institutional Survey of Squamous Cell Carcinoma of the External Auditory Canal in Japan

被引：13

作者：

Shiga, Kiyoto ^{[1
]}

Nibu, Ken-ichi ^{[2
]}

Fujimoto, Yasushi ^{[3
]}

Asakage, Takahiro ^{[4
]}

Homma, Akihiro ^{[5
,6
]}

Mitani, Hiroki ^{[7
]}

Ogawa, Takenori ^{[8
]}

Okami, Kenji ^{[9
]}

Murono, Shigeyuki ^{[10
]}

Hirano, Shigeru ^{[11
]}

Ueda, Tsutomu ^{[12
]}

Hanai, Nobuhiro ^{[13
]}

Tsukahara, Kiyoaki ^{[14
]}

Ota, Ichiro ^{[15
]}

Yoshimoto, Seiichi ^{[16
]}

Shinozaki, Takeshi ^{[17
]}

Iwae, Shigemichi ^{[18
]}

Katagiri, Katsunori ^{[1
]}

Saito, Daisuke ^{[1
]}

Kiyota, Naomi ^{[19
]}

Tahara, Makoto ^{[20
]}

Takahashi, Fumiaki ^{[21
]}

Hayashi, Ryuichi ^{[17
]}

机构：

[1] Iwate Med Univ, Sch Med, Dept Head & Neck Surg, Yahaba, Iwate, Japan

[2] Kobe Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Kobe, Hyogo, Japan

[3] Nagoya Univ, Grad Sch Med, Dept Otorhinolaryngol, Nagoya, Aichi, Japan

[4] Tokyo Med & Dent Univ, Dept Head & Neck Surg, Bunkyo Ku, Tokyo, Japan

[5] Hokkaido Univ, Fac Med, Dept Otolaryngol Head & Neck Surg, Sapporo, Hokkaido, Japan

[6] Hokkaido Univ, Grad Sch Med, Sapporo, Hokkaido, Japan

[7] JFCR, Canc Inst Hosp, Dept Head & Neck Surg, Tokyo, Japan

[8] Tohoku Univ Hosp, Dept Otolaryngol Head & Neck Surg, Sendai, Miyagi, Japan

[9] Tokai Univ, Sch Med, Dept Otolaryngol, Hiratsuka, Kanagawa, Japan

[10] Fukushima Med Univ, Dept Otolaryngol, Fukushima, Japan

[11] Kyoto Prefectural Univ Med, Dept Otolaryngol Head & Neck Surg, Kyoto, Japan

[12] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Otorhinolaryngol Head & Neck Surg, Higashihiroshima, Japan

[13] Aichi Canc Ctr Hosp, Dept Head & Neck Surg, Nagoya, Aichi, Japan

[14] Tokyo Med Univ, Dept Otorhinolaryngol Head & Neck Surg, Shinjuku Ku, Tokyo, Japan

[15] Nara Med Univ, Dept Otolaryngol Head & Neck Surg, Kashihara, Nara, Japan

[16] Natl Canc Ctr, Dept Head & Neck Surg, Tokyo, Japan

[17] Natl Canc Ctr Hosp East, Dept Head & Neck Surg, Kashiwa, Chiba, Japan

[18] Hyogo Canc Ctr, Dept Head & Neck Surg, Akashi, Hyogo, Japan

[19] Kobe Univ Hosp, Ctr Canc, Dept Med Oncol Hematol, Kobe, Hyogo, Japan

[20] Natl Canc Ctr Hosp East, Dept Head & Neck Med Oncol, Kashiwa, Chiba, Japan

[21] Iwate Med Univ, Dept Informat Sci, Div Med Engn, Yahaba, Iwate, Japan

来源：

LARYNGOSCOPE | 2021年 / 131卷 / 03期

关键词：

Squamous cell carcinoma; external auditory canal; chemoradiotherapy; multi-institutional study; TEMPORAL BONE RESECTION; CONCOMITANT CHEMORADIOTHERAPY; MIDDLE-EAR; OUTCOMES; SURGERY;

D O I：

10.1002/lary.28936

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objectives This study aimed to evaluate the efficacy of chemoradiotherapy (CRT) for patients with advanced cancer of the external auditory canal (EAC) by analyzing the outcome of the patients. Methods This is a multi-institutional retrospective survey, and we reviewed the medical records of the subjects. A total of 181 patients with tumor (T)3 or T4 tumor in 17 institutions were enrolled. Further analysis was performed for 74 patients who underwent CRT under curative intent. Results Overall 5-year survival rates of the patients who underwent CRT (n = 74) were 54.6%. Those of the patients who underwent CRT with modified TPF (docetaxel, cisplatin [CDDP], and 5-fluorouracil) regimen (n = 50) and CRT with CDDP regimens (n = 24) were 64.4% and 36.7%, respectively. Significant differences were observed between these two groups. Conclusion Given the tendency that head and neck surgeons prefer CRT for advanced larger cancer of the EAC, CRT for advanced EAC cancer using the modified TPF regimen showed good clinical outcomes. Level of Evidence 4Laryngoscope, 2020

引用

页码：E870 / E874

页数：5

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