Nickel-Catalyzed Heck-Type Monofluoroacetation of Styrenes for Facile Synthesis of Allylic Fluorides

被引：19

作者：

Wang, Zhen-Yu ^{[1
,2
]}

Wan, Jia-Hao ^{[1
,2
]}

Wang, Gao-Yin ^{[1
,2
]}

Jin, Ruo-Xing ^{[1
,2
]}

Lan, Quan ^{[1
,2
]}

Wang, Xi-Sheng ^{[1
,2
]}

机构：

[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China

[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2018年 / 13卷 / 03期

基金：

美国国家科学基金会;

关键词：

allylic fluorides; catalysis; Heck-type; nickel-catalyzed; radicals; styrenes; LIGHT PHOTOREDOX CATALYSIS; CROSS-COUPLING REACTIONS; REDOX-ACTIVE ESTERS; ARYL BORONIC ACIDS; ENANTIOSELECTIVE FLUORINATION; (2-PYRIDYL)SULFONYL GROUP; DIRECT FUNCTIONALIZATION; ASYMMETRIC-SYNTHESIS; FLUOROMETHYL IODIDE; MEDICINAL CHEMISTRY;

D O I：

10.1002/asia.201701655

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient nickel-catalyzed Heck-type reaction between styrenes and fluoroalkyl iodine has been developed. This novel transformation has demonstrated a broad substrate scope, mild reaction conditions and excellent E-stereoselectivity. This efficient synthetic method has been applied to the late-stage monofluoroacetation of biologically active molecules. Mechanistic investigations indicate that a monofluoroalkyl radical is involved in the catalytic cycle.

引用

页码：261 / 265

页数：5

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