Preparation and characterizations of EGDE crosslinked chitosan electrospun membranes

被引：17

作者：

Aqil, A. ^{[1
]}

Tchemtchoua, V. T. ^{[2
]}

Colige, A. ^{[2
]}

Atanasova, G. ^{[3
]}

Poumay, Y. ^{[3
]}

Jerome, C. ^{[1
]}

机构：

[1] Univ Liege, Inst Chim, Ctr Macromol Study & Res, B-4000 Liege, Belgium

[2] Univ Liege, GIGA Res Ctr, Lab Connect Tissues Biol, B-4000 Liege, Belgium

[3] Univ Namur FUNDP, Lab Cells & Tissues, Namur, Belgium

来源：

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION | 2015年 / 60卷 / 01期

关键词：

Chitosan; electrospinning; crosslinking; mechanical properties; tissue engineering; cytotoxicity; ACETIC-ACID; CHITIN; NANOFIBERS; FIBER;

D O I：

10.3233/CH-151930

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Composite Crosslinked nanofibrous membranes of chitosan, ethylene glycol diglycidyl ether (EGDE) and polyethylene oxide was successfully prepared with bead free morphology via electrospinning technique followed by heat mediated chemical crosslinking. Architectural stability of nanofiber mat in aqueous medium was achieved by chemical crosslinking of only 1% EGDE, and tensile strength tests revealed that increasing EGDE content has considerably enhance the elastic modulus of nanofibers. The structure, morphology and mechanical properties of nanofibers were characterized by Attenuated Total Reflection-Fourier Transform Infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM) and Instron machine, respectively. Skin fibroblasts and endothelial cells showed good attachment, proliferation and viability on crosslinked electrospun membranes. The results indicate a good biocompatibility and non-toxic nature of the resulted membrane.

引用

页码：39 / 50

页数：12

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