Fractal Analysis of Two-Photon Microscopic Images for Diagnosis of Nasopharyngeal Cancer

被引：7

作者：

Huang, Zufang

Pan, Jianji ^{[2
]}

Chen, Guannan ^{[1
]}

Li, Zuanfang ^{[3
]}

Chen, Xiwen

Li, Yongzeng

Wang, Jing

Chen, Rong

机构：

[1] Fujian Normal Univ, Sch Phys & Optoelect Technol, Fujian Prov Key Lab Photon Technol, Key Lab Optoelect Sci & Technol Med,Minist Educ, Fuzhou 350007, Peoples R China

[2] Fujian Prov Tumor Hosp, Fuzhou, Peoples R China

[3] Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou, Peoples R China

来源：

SCANNING | 2012年 / 34卷 / 06期

基金：

中国国家自然科学基金;

关键词：

two-photon microscopy; nasopharyngeal tissue; fractal dimension; nuclear-cytoplasmic ratio; FLUORESCENCE SPECTROSCOPY; AUTOFLUORESCENCE; CARCINOMA; LESIONS;

D O I：

10.1002/sca.21023

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

In this study, two-photon microscopy (TPM) was applied to obtain high-resolution, optically sectioned images with cellular morphology information from normal and cancerous nasopharyngeal tissue. Notable difference of nuclear-cytoplasmic ratio was found between these two groups. In particular, fractal dimension (FD) analysis based on TPM images showed good differentiation between normal and cancerous nasopharyngeal tissues. Our results indicate that TPM coupled with FD analysis methods has the potential to extract diagnostic features for label-free histological diagnosis. SCANNING 34: 399-403, 2012. (c) 2012 Wiley Periodicals, Inc.

引用

页码：399 / 403

页数：5

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