Memory-enhancing, Antioxidant, and Anticholinesterase Effects of Inhaled Achillea pseudoaleppica Essential Oil on Scopolamine-induced Amnesic Rats

被引:1
作者
Akbaba, Emel [1 ,2 ]
Bagci, Eyup [1 ]
机构
[1] Firat Univ, Fac Sci, Dept Biol, TR-23119 Elazig, Turkey
[2] Kirikkale Univ, Fac Med, Dept Med Biol, TR-71450 Kirikkale, Turkey
关键词
Achillea pseudoaleppica essential oil; Scopolamine; Memory; Y-maze; Radial-arm maze; ANGULATA ESSENTIAL OIL; OXIDATIVE STRESS; INSECTICIDAL PROPERTIES; CHEMICAL-COMPOSITION; SNAIL NEURONS; IMPAIRMENT; MILLEFOLIUM; INHALATION; DISEASE; DEPRESSION;
D O I
10.1080/0972060X.2022.2121617
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Achillea species are used for therapeutic purposes in many countries. This study demonstrated the memory-enhancing, antioxidant, and anticholinesterase effects of Achillea pseudoaleppica essential oil in scopolamine-induced amnesia. The GC/FID-GC/MS system revealed camphor as the major compound in the oil. The application of the essential oil (1% and 3%) was performed on the rats by inhalation for 21 consecutive days before the performance of the behavioral tests (Y-maze and radial-arm maze tests). The essential oil application increased the spontaneous alternation behavior in scopolamine-induced rats in the Y-maze task. Furthermore, essential oil administration decreased working memory errors and reference memory errors in scopolamine-treated rats in the radial-arm maze test. Therefore, Achillea pseudoaleppica essential oil inhalation improved memory in scopolamine-treated rats. In addition, acetylcholinesterase and antioxidant profiles of the hippocampal tissues of the rats were examined. Essential oil administration decreased acetylcholinesterase and superoxide dismutase specific activities and malondialdehyde levels while increasing the total content of reduced glutathione in the rat hippocampus in scopolamine-treated rats. Therefore, in this study, the combination of scopolamine and Achillea pseudoaleppica essential oil improved memory formation and increased the activities of antioxidants and anticholinesterase.
引用
收藏
页码:859 / 875
页数:17
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