Enhanced anti-cancer activities of a gold(III) pyrrolidinedithiocarbamato complex incorporated in a biodegradable metal-organic framework

被引：28
|
作者：
Sun, Raymond Wai-Yin [1 ,2 ]
Zhang, Ming [1 ,2 ]
Li, Dan [1 ,2 ]
Li, Mian [1 ,2 ]
Wong, Alice Sze-Tsai [3 ]
机构：
[1] Shantou Univ, Dept Chem, 243 Da Xue Rd, Shantou 515063, Guangdong, Peoples R China
[2] Shantou Univ, Key Lab Preparat & Applicat Ordered Struct Mat Gu, 243 Da Xue Rd, Shantou 515063, Guangdong, Peoples R China
[3] Univ Hong Kong, Sch Biol Sci, Pokfulam, Hong Kong, Peoples R China
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2016年 / 163卷
基金：
美国国家卫生研究院; 中国国家自然科学基金;
关键词：
Cancer; Carbene; Dithiocarbamate; Gold; Metal-organic framework; BREAST-CANCER CELLS; SOLUTION CHEMISTRY; PYRROLIDINE DITHIOCARBAMATE; PORPHYRIN COMPLEX; DRUG-DELIVERY; DESIGN; AGENTS; PROTEASOME; CHEMOTHERAPY; DERIVATIVES;
D O I：
10.1016/j.jinorgbio.2016.06.020
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
An anti-cancer active gold(III) pyrrolidinedithiocarbamato complex [(PDTC)(AuCl2)-Cl-III] (1) has been synthesized and characterized by means of X-ray crystallography. Compared to the pyrrolidinedithiocarbamate ligand itself, this gold(III) complex displays an up to 33-fold higher anti-cancer potency towards a panel of cancer cell lines including the cisplatin-resistant ovarian carcinoma cell line (A2780cis). As demonstrated by a set of Transwell assay-based cytotoxicity experiments, incorporating this gold(III) complex in a zinc-based biodegradable metal organic framework (MOF) displays a significant enhancement in anti-cancer activity towards A2780cis than the gold(III) complex alone. (C) 2016 Elsevier Inc All rights reserved.
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页码：1 / 7
页数：7
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