Safety of potential breast milk exposure to IFN-β or glatiramer acetate One-year infant outcomes
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作者:
Ciplea, Andrea Ines
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Ruhr Univ Bochum, St Josef Hosp, Dept Neurol, Bochum, Germany
Heinrich Heine Univ, Inst Clin Pharm & Pharmacotherapy, Dusseldorf, GermanyRuhr Univ Bochum, St Josef Hosp, Dept Neurol, Bochum, Germany
Ciplea, Andrea Ines
[1
,2
]
Langer-Gould, Annette
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Los Angeles Med Ctr, Kaiser Permanente, Southern Calif Permanente Med Grp, Dept Neurol, Los Angeles, CA USARuhr Univ Bochum, St Josef Hosp, Dept Neurol, Bochum, Germany
Langer-Gould, Annette
[3
]
Stahl, Anna
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机构:
Ruhr Univ Bochum, St Josef Hosp, Dept Paediat, Bochum, GermanyRuhr Univ Bochum, St Josef Hosp, Dept Neurol, Bochum, Germany
Stahl, Anna
[4
]
Thiel, Sandra
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Ruhr Univ Bochum, St Josef Hosp, Dept Neurol, Bochum, GermanyRuhr Univ Bochum, St Josef Hosp, Dept Neurol, Bochum, Germany
Thiel, Sandra
[1
]
Queisser-Wahrendorf, Annette
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Johannes Gutenberg Univ Mainz, Ctr Paediat & Youth Med, Mainz, GermanyRuhr Univ Bochum, St Josef Hosp, Dept Neurol, Bochum, Germany
Queisser-Wahrendorf, Annette
[5
]
Gold, Ralf
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Ruhr Univ Bochum, St Josef Hosp, Dept Neurol, Bochum, GermanyRuhr Univ Bochum, St Josef Hosp, Dept Neurol, Bochum, Germany
Gold, Ralf
[1
]
Hellwig, Kerstin
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Ruhr Univ Bochum, St Josef Hosp, Dept Neurol, Bochum, GermanyRuhr Univ Bochum, St Josef Hosp, Dept Neurol, Bochum, Germany
Hellwig, Kerstin
[1
]
机构:
[1] Ruhr Univ Bochum, St Josef Hosp, Dept Neurol, Bochum, Germany
Objective To determine whether potential breast milk exposure to interferon-beta (IFN-beta) or glatiramer acetate (GA) is safe for the infant. Methods We identified 74 infants born to 69 women with MS who breastfed under IFN-beta (n = 39), GA (n = 34), or both (n = 1). Women had been enrolled into the German Multiple Sclerosis and Pregnancy Registry during pregnancy. Data were obtained from standardized, telephone-administered questionnaires completed by the mother during pregnancy and at 1, 3, 6, and 12 months postpartum and the infant's take-home medical record. Results The median duration of exposed breastfeeding was 8.5 months (wide interquartile range: 4.9-12.7 months). Physical growth curves during the first year of life were consistent with national, sex-specific growth curves. Median body measurements were consistent with national medians. Most children (n = 71, 96%) had normal motor and language development. Gross motor delay was reported in 3 children, of whom 1 remained delayed at last follow-up (3.9 years old) and 2 were normal by 0.9 and 4.1 years old. The proportion of children hospitalized at least once (girls n = 2, 7%, and boys n = 6, 14%) and the proportion of children with at least one episode of systemic antibiotic use during the first year of life (girls n = 7, 23%, and boys n = 8, 18%) are consistent with national averages. Conclusion Potential breast milk exposure to IFN-beta or GA did not increase the risk of common adverse infant outcomes in the first year of life. Taken together with the benefits of breastfeeding and low biological plausibility of risk, women with MS who wish to resume IFN-beta or GA postpartum can be encouraged to breastfeed.
机构:
Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USAUniv Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA
Anderson, P. O.
Sauberan, J. B.
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Sharp Mary Birch Hosp Women & Newborns, Neonatal Res Inst, San Diego, CA USAUniv Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA
机构:
Cincinnati Childrens Hosp Med Ctr, Div Immunobiol, Ctr Interdisciplinary Res Human Milk & Lactat, Cincinnati, OH 45229 USACincinnati Childrens Hosp Med Ctr, Div Immunobiol, Ctr Interdisciplinary Res Human Milk & Lactat, Cincinnati, OH 45229 USA
Ballard, Olivia
Morrow, Ardythe L.
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Cincinnati Childrens Hosp Med Ctr, Ctr Interdisciplinary Res Human Milk & Lactat, Perinatal Inst, Cincinnati, OH 45229 USACincinnati Childrens Hosp Med Ctr, Div Immunobiol, Ctr Interdisciplinary Res Human Milk & Lactat, Cincinnati, OH 45229 USA
机构:
Ctr Hlth Res & Dev, Soc Appl Studies, New Delhi 110016, IndiaCtr Hlth Res & Dev, Soc Appl Studies, New Delhi 110016, India
Chowdhury, Ranadip
Sinha, Bireshwar
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Ctr Hlth Res & Dev, Soc Appl Studies, New Delhi 110016, IndiaCtr Hlth Res & Dev, Soc Appl Studies, New Delhi 110016, India
Sinha, Bireshwar
Sankar, Mari Jeeva
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机构:
All India Inst Med Sci, Dept Paediat, ICMR Ctr Adv Res Newborn Hlth, Newborn Hlth Knowledge Ctr, New Delhi, IndiaCtr Hlth Res & Dev, Soc Appl Studies, New Delhi 110016, India
Sankar, Mari Jeeva
Taneja, Sunita
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Ctr Hlth Res & Dev, Soc Appl Studies, New Delhi 110016, IndiaCtr Hlth Res & Dev, Soc Appl Studies, New Delhi 110016, India
Taneja, Sunita
Bhandari, Nita
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Ctr Hlth Res & Dev, Soc Appl Studies, New Delhi 110016, IndiaCtr Hlth Res & Dev, Soc Appl Studies, New Delhi 110016, India
Bhandari, Nita
Rollins, Nigel
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机构:
WHO, Dept Maternal Newborn Child & Adolescent Hlth, CH-1211 Geneva, SwitzerlandCtr Hlth Res & Dev, Soc Appl Studies, New Delhi 110016, India
Rollins, Nigel
Bahl, Rajiv
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WHO, Dept Maternal Newborn Child & Adolescent Hlth, CH-1211 Geneva, SwitzerlandCtr Hlth Res & Dev, Soc Appl Studies, New Delhi 110016, India
Bahl, Rajiv
Martines, Jose
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机构:
Univ Bergen, Ctr Int Hlth, Ctr Intervent Sci Maternal & Child Hlth, Bergen, NorwayCtr Hlth Res & Dev, Soc Appl Studies, New Delhi 110016, India
机构:
Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USAUniv Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA
Anderson, P. O.
Sauberan, J. B.
论文数: 0引用数: 0
h-index: 0
机构:
Sharp Mary Birch Hosp Women & Newborns, Neonatal Res Inst, San Diego, CA USAUniv Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA
机构:
Cincinnati Childrens Hosp Med Ctr, Div Immunobiol, Ctr Interdisciplinary Res Human Milk & Lactat, Cincinnati, OH 45229 USACincinnati Childrens Hosp Med Ctr, Div Immunobiol, Ctr Interdisciplinary Res Human Milk & Lactat, Cincinnati, OH 45229 USA
Ballard, Olivia
Morrow, Ardythe L.
论文数: 0引用数: 0
h-index: 0
机构:
Cincinnati Childrens Hosp Med Ctr, Ctr Interdisciplinary Res Human Milk & Lactat, Perinatal Inst, Cincinnati, OH 45229 USACincinnati Childrens Hosp Med Ctr, Div Immunobiol, Ctr Interdisciplinary Res Human Milk & Lactat, Cincinnati, OH 45229 USA
机构:
Ctr Hlth Res & Dev, Soc Appl Studies, New Delhi 110016, IndiaCtr Hlth Res & Dev, Soc Appl Studies, New Delhi 110016, India
Chowdhury, Ranadip
Sinha, Bireshwar
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Hlth Res & Dev, Soc Appl Studies, New Delhi 110016, IndiaCtr Hlth Res & Dev, Soc Appl Studies, New Delhi 110016, India
Sinha, Bireshwar
Sankar, Mari Jeeva
论文数: 0引用数: 0
h-index: 0
机构:
All India Inst Med Sci, Dept Paediat, ICMR Ctr Adv Res Newborn Hlth, Newborn Hlth Knowledge Ctr, New Delhi, IndiaCtr Hlth Res & Dev, Soc Appl Studies, New Delhi 110016, India
Sankar, Mari Jeeva
Taneja, Sunita
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Hlth Res & Dev, Soc Appl Studies, New Delhi 110016, IndiaCtr Hlth Res & Dev, Soc Appl Studies, New Delhi 110016, India
Taneja, Sunita
Bhandari, Nita
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h-index: 0
机构:
Ctr Hlth Res & Dev, Soc Appl Studies, New Delhi 110016, IndiaCtr Hlth Res & Dev, Soc Appl Studies, New Delhi 110016, India
Bhandari, Nita
Rollins, Nigel
论文数: 0引用数: 0
h-index: 0
机构:
WHO, Dept Maternal Newborn Child & Adolescent Hlth, CH-1211 Geneva, SwitzerlandCtr Hlth Res & Dev, Soc Appl Studies, New Delhi 110016, India
Rollins, Nigel
Bahl, Rajiv
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h-index: 0
机构:
WHO, Dept Maternal Newborn Child & Adolescent Hlth, CH-1211 Geneva, SwitzerlandCtr Hlth Res & Dev, Soc Appl Studies, New Delhi 110016, India
Bahl, Rajiv
Martines, Jose
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机构:
Univ Bergen, Ctr Int Hlth, Ctr Intervent Sci Maternal & Child Hlth, Bergen, NorwayCtr Hlth Res & Dev, Soc Appl Studies, New Delhi 110016, India