Safety of potential breast milk exposure to IFN-β or glatiramer acetate One-year infant outcomes

被引:31
作者
Ciplea, Andrea Ines [1 ,2 ]
Langer-Gould, Annette [3 ]
Stahl, Anna [4 ]
Thiel, Sandra [1 ]
Queisser-Wahrendorf, Annette [5 ]
Gold, Ralf [1 ]
Hellwig, Kerstin [1 ]
机构
[1] Ruhr Univ Bochum, St Josef Hosp, Dept Neurol, Bochum, Germany
[2] Heinrich Heine Univ, Inst Clin Pharm & Pharmacotherapy, Dusseldorf, Germany
[3] Los Angeles Med Ctr, Kaiser Permanente, Southern Calif Permanente Med Grp, Dept Neurol, Los Angeles, CA USA
[4] Ruhr Univ Bochum, St Josef Hosp, Dept Paediat, Bochum, Germany
[5] Johannes Gutenberg Univ Mainz, Ctr Paediat & Youth Med, Mainz, Germany
来源
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION | 2020年 / 7卷 / 04期
关键词
MULTIPLE-SCLEROSIS; INTERFERON-BETA; DOUBLE-BLIND; PREGNANCY; WOMEN; RISK; PHARMACOKINETICS; MULTICENTER; DRUGS;
D O I
10.1212/NXI.0000000000000757
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective To determine whether potential breast milk exposure to interferon-beta (IFN-beta) or glatiramer acetate (GA) is safe for the infant. Methods We identified 74 infants born to 69 women with MS who breastfed under IFN-beta (n = 39), GA (n = 34), or both (n = 1). Women had been enrolled into the German Multiple Sclerosis and Pregnancy Registry during pregnancy. Data were obtained from standardized, telephone-administered questionnaires completed by the mother during pregnancy and at 1, 3, 6, and 12 months postpartum and the infant's take-home medical record. Results The median duration of exposed breastfeeding was 8.5 months (wide interquartile range: 4.9-12.7 months). Physical growth curves during the first year of life were consistent with national, sex-specific growth curves. Median body measurements were consistent with national medians. Most children (n = 71, 96%) had normal motor and language development. Gross motor delay was reported in 3 children, of whom 1 remained delayed at last follow-up (3.9 years old) and 2 were normal by 0.9 and 4.1 years old. The proportion of children hospitalized at least once (girls n = 2, 7%, and boys n = 6, 14%) and the proportion of children with at least one episode of systemic antibiotic use during the first year of life (girls n = 7, 23%, and boys n = 8, 18%) are consistent with national averages. Conclusion Potential breast milk exposure to IFN-beta or GA did not increase the risk of common adverse infant outcomes in the first year of life. Taken together with the benefits of breastfeeding and low biological plausibility of risk, women with MS who wish to resume IFN-beta or GA postpartum can be encouraged to breastfeed.
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页数:9
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