Cyclization Reactions of Anode-Generated Amidyl Radicals

被引：93
作者：
Xu, Hai-Chao [1 ,2 ]
Campbell, John M. [3 ]
Moeller, Kevin D. [3 ]
机构：
[1] Xiamen Univ, Coll Chem & Chem Engn, Dept Chem, Xiamen 361005, Fujian, Peoples R China
[2] Xiamen Univ, Coll Chem & Chem Engn, Fujian Prov Key Lab Chem Biol, Xiamen 361005, Fujian, Peoples R China
[3] Washington Univ, Dept Chem, St Louis, MO 63130 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 01期
基金：
美国国家科学基金会;
关键词：
OLEFIN COUPLING REACTIONS; COPPER(I)-CATALYZED INTRAMOLECULAR ADDITION; MAIN-GROUP THERMOCHEMISTRY; N-CHLORO AMIDES; DOUBLE-BONDS; OXIDATIVE CYCLIZATION; MICROBIAL METABOLITE; DENSITY FUNCTIONALS; RATE CONSTANTS; KINETICS;
D O I：
10.1021/jo402623r
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Amidyl radicals have been generated from amides under mild conditions electro-oxidatively. Their reactivity toward electron-rich double bonds to form five- and six-membered rings has been demonstrated experimentally and explored with density functional theory (DFT) calculations (UB3LYP/6-31G(d,p)).
引用
收藏
页码：379 / 391
页数：13
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