Identification of a Neuropeptide S Responsive Circuitry Shaping Amygdala Activity via the Endopiriform Nucleus

被引：100

作者：

Meis, Susanne ^{[1
]}

Bergado-Acosta, Jorge Ricardo ^{[1
,2
]}

Yanagawa, Yuchio ^{[3
]}

Obata, Kunihiko ^{[4
]}

Stork, Oliver ^{[1
,2
]}

Munsch, Thomas ^{[1
]}

机构：

[1] Otto Von Guericke Univ, Inst Physiol, Magdeburg, Germany

[2] Otto von Guericke Univ, Inst Biol, Abt Mol Neurobiol, Magdeburg, Germany

[3] Gunma Univ, Grad Sch Med, Dept Genet & Behav Neurosci, Maebashi, Gunma, Japan

[4] RIKEN Brain Sci Inst, Obata Res Unit, Neuronal Circuit Mechanisms Res Grp, Wako, Saitama, Japan

来源：

PLOS ONE | 2008年 / 3卷 / 07期

关键词：

D O I：

10.1371/journal.pone.0002695

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Neuropeptide S (NPS) and its receptor are thought to define a set of specific brain circuits involved in fear and anxiety. Here we provide evidence for a novel, NPS-responsive circuit that shapes neural activity in the mouse basolateral amygdala (BLA) via the endopiriform nucleus (EPN). Using slice preparations, we demonstrate that NPS directly activates an inward current in 20% of EPN neurons and evokes an increase of glutamatergic excitation in this nucleus. Excitation of the EPN is responsible for a modulation of BLA activity through NPS, characterized by a general increase of GABAergic inhibition and enhancement of spike activity in a subset of BLA projection neurons. Finally, local injection of NPS to the EPN interferes with the expression of contextual, but not auditory cued fear memory. Together, these data suggest the existence of a specific NPS-responsive circuitry between EPN and BLA, likely involved in contextual aspects of fear memory.

引用

页数：11

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