DMAP-promoted domino annulation of β-ketothioamides with internal alkynes: a highly regioselective access to functionalized 1,3-thiazolidin-4-ones at room temperature

被引：23

作者：

Verma, Girijesh Kumar ^{[1
]}

Shukla, Gaurav ^{[1
]}

Nagaraju, Anugula ^{[1
]}

Srivastava, Abhijeet ^{[1
]}

Raghuvanshi, Keshav ^{[2
]}

Singh, Maya Shankar ^{[1
]}

机构：

[1] Banaras Hindu Univ, Fac Sci, Dept Chem, Varanasi 221005, Uttar Pradesh, India

[2] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

来源：

RSC ADVANCES | 2014年 / 4卷 / 23期

关键词：

ONE-POT SYNTHESIS; N; S-KETENE ACETAL; EFFICIENT; DESIGN; CONSTRUCTION; DERIVATIVES; REACTIVITY; DYE;

D O I：

10.1039/c4ra00131a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

DMAP-mediated rapid and efficient one-pot regioselective access to functionalized 1,3-thiazolidin-4-ones via annulation of beta-ketothioamides with internal alkynes has been achieved under mild reaction conditions. The merit of this straightforward domino protocol is highlighted by its operational simplicity, short reaction time, tolerance of a large variety of functional groups, and efficiency of producing two new bonds (C-S and C-N) and one thiazolidine ring.

引用

页码：11640 / 11647

页数：8

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