The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality

被引：147
作者：
Gustafsson, David [1 ]
Unwin, Robert [2 ]
机构：
[1] AstraZeneca R&D, CVMD iMED, Biosci, Molndal, Sweden
[2] UCL, UCL Ctr Nephrol, London, England
来源：
BMC NEPHROLOGY | 2013年 / 14卷
关键词：
Uric acid; Urate; Hypertension; Chronic kidney disease; Congestive heart failure; Type 2 diabetes mellitus; Metabolic syndrome; Cardiovascular events; Atherosclerosis; SERUM URIC-ACID; CHRONIC KIDNEY-DISEASE; HIGH-DOSE ALLOPURINOL; BLOOD-PRESSURE; HEART-FAILURE; METABOLIC SYNDROME; MECHANISTIC INSIGHTS; ENDOTHELIAL FUNCTION; URATE; RISK;
D O I：
10.1186/1471-2369-14-164
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Uric acid is the end product of purine metabolism in humans. High levels are causative in gout and urolithiasis. Hyperuricaemia has also been implicated in the pathophysiology of hypertension, chronic kidney disease (CKD), congestive heart failure (CHF), the metabolic syndrome, type 2 diabetes mellitus (T2DM), and atherosclerosis, with or without cardiovascular events. This article briefly reviews uric acid metabolism and summarizes the current literature on hyperuricaemia in cardiovascular disease and related co-morbidities, and emerging treatment options.
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页数：9
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