Design, Synthesis, Biological Evaluation and SARs of Anthranilic Diamide Derivatives Containing Pyrrole Moieties

In order to find a new variety of ryanodine receptor(RyR) regulator with greater biological activity, a series of anthranilic diamide derivatives possessing pyrrole structure was designed and synthesized in this study. The pyrrole derivatives were evaluated for their insecticidal activity againstMythimna separataandPlutella xylostella. As indicated by the preliminary biological activities, compounds12h-12j and12l-12n exhibited a remarkable insecticidal activity againstM. separataat 0.25 mg/L. Compared to control chlorantraniliprole, compound12j exhibited more excellent insecticidal activity at 0.1 mg/L. Meanwhile, compounds12c,12h,12i,12j,12l, and12m were selected to test the insecticidal activity againstP. xylostella, which led to the desirable insecticidal activity at 1x10(-3)mg/L. Notably, compound12l demonstrated 47% insecticidal activity at 5x10(-6)mg/L over the control. In addition, the biological mechanism of action of compound12j was investigated by means of insect electrophysiology experiment.