Grating-based interferometry and hybrid photon counting detectors: Towards a new era in X-ray medical imaging

Progress in X-ray medical imaging and advances in detector developments have always been closely related. Similarly, a strong connection exists between innovations in synchrotron imaging and their implementation on table-top X-ray tube setups. The transfer of phase-based imaging to X-ray tubes can provide table-top setups with improved contrast between areas of low attenuation differences, by exploiting the unit decrement of the real part of the refractive index. Medical imaging is a potential application for such a system. Originally developed for synchrotron experiments, the novel generation of hybrid photon counting detectors is becoming increasingly popular due to their unique characteristics, such as small pixel size, negligible dark noise, fast counting and adjustable energy thresholds. Furthermore, novel room temperature semiconductor materials such as Cd(Zn)Te can provide higher quantum efficiency. In the first part of this article we review phase-contrast techniques and recent research towards medical applications. In the second part we present results and evaluate the potential of combining a table-top Talbot grating interferometry system with latest generation hybrid photon counting detectors. (C) 2015 Elsevier B.V. All rights reserved.