Stability and biocompatibility of photothermal gold nanorods after lyophilization and sterilization

被引:12
作者
Gomez, Leyre [1 ]
Cebrian, Virginia [2 ,3 ]
Martin-Saavedra, Francisco [2 ,3 ]
Arruebo, Manuel [1 ,2 ]
Vilaboa, Nuria [2 ,3 ]
Santamaria, Jesus [1 ,2 ]
机构
[1] Univ Zaragoza, Dept Chem Engn, INA, Zaragoza 50018, Spain
[2] CIBER BBN, CIBER Bioingn Biomat & Nanomed, Zaragoza, Spain
[3] Hosp Univ La Paz IdiPAZ, Madrid 28046, Spain
关键词
nanostructures; metals; optical properties; chemical synthesis; SURFACE; NANOPARTICLES; SCATTERING; BROMIDE;
D O I
10.1016/j.materresbull.2013.06.034
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Suspensions in phosphate buffered saline (PBS) of gold nanorods stabilized with cetyltrimethyl ammonium chloride (CTABr), polystyrenesulfonate (PSS) and methyl-polyethyleneglycol-thiol (m-PEG-SH) have been prepared and the evolution of their colloidal stability and plasmonic response over time has been evaluated. Their performance after lyophilization, alcoholic sterilization and resuspension has also been characterized. Sub-cytotoxic doses on HeLa cells were calculated for the three surface functionalizations used. Their heating efficiency at different exposure times was also evaluated after being irradiated with near infrared light. The best results were obtained for m-PEG-SH stabilized rods, which were not only stable, sterilizable and lyophilizable, but also biocompatible at all doses tested, showing potential as a stable, re-suspendible and biocompatible hyperthermic agent. (c) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码:4051 / 4057
页数:7
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