Stability and biocompatibility of photothermal gold nanorods after lyophilization and sterilization

被引：12
作者：
Gomez, Leyre [1 ]
Cebrian, Virginia [2 ,3 ]
Martin-Saavedra, Francisco [2 ,3 ]
Arruebo, Manuel [1 ,2 ]
Vilaboa, Nuria [2 ,3 ]
Santamaria, Jesus [1 ,2 ]
机构：
[1] Univ Zaragoza, Dept Chem Engn, INA, Zaragoza 50018, Spain
[2] CIBER BBN, CIBER Bioingn Biomat & Nanomed, Zaragoza, Spain
[3] Hosp Univ La Paz IdiPAZ, Madrid 28046, Spain
来源：
MATERIALS RESEARCH BULLETIN | 2013年 / 48卷 / 10期
关键词：
nanostructures; metals; optical properties; chemical synthesis; SURFACE; NANOPARTICLES; SCATTERING; BROMIDE;
D O I：
10.1016/j.materresbull.2013.06.034
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Suspensions in phosphate buffered saline (PBS) of gold nanorods stabilized with cetyltrimethyl ammonium chloride (CTABr), polystyrenesulfonate (PSS) and methyl-polyethyleneglycol-thiol (m-PEG-SH) have been prepared and the evolution of their colloidal stability and plasmonic response over time has been evaluated. Their performance after lyophilization, alcoholic sterilization and resuspension has also been characterized. Sub-cytotoxic doses on HeLa cells were calculated for the three surface functionalizations used. Their heating efficiency at different exposure times was also evaluated after being irradiated with near infrared light. The best results were obtained for m-PEG-SH stabilized rods, which were not only stable, sterilizable and lyophilizable, but also biocompatible at all doses tested, showing potential as a stable, re-suspendible and biocompatible hyperthermic agent. (c) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4051 / 4057
页数：7
相关论文
共 39 条
  • [1] Dynamic Imaging of Molecular Assemblies in Live Cells Based on Nanoparticle Plasmon Resonance Coupling
    Aaron, Jesse
    Travis, Kort
    Harrison, Nathan
    Sokolov, Konstantin
    [J]. NANO LETTERS, 2009, 9 (10) : 3612 - 3618
  • [2] Cellular Uptake and Cytotoxicity of Gold Nanorods: Molecular Origin of Cytotoxicity and Surface Effects
    Alkilany, Alaaldin M.
    Nagaria, Pratik K.
    Hexel, Cole R.
    Shaw, Timothy J.
    Murphy, Catherine J.
    Wyatt, Michael D.
    [J]. SMALL, 2009, 5 (06) : 701 - 708
  • [3] Gold nanorods 3D-supercrystals as surface enhanced Raman scattering spectroscopy substrates for the rapid detection of scrambled prions
    Alvarez-Puebla, Ramon A.
    Agarwal, Ashish
    Manna, Pramit
    Khanal, Bishnu P.
    Aldeanueva-Potel, Paula
    Carbo-Argibay, Enrique
    Pazos-Perez, Nicolas
    Vigderman, Leonid
    Zubarev, Eugene R.
    Kotov, Nicholas A.
    Liz-Marzan, Luis M.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (20) : 8157 - 8161
  • [4] Single metallic nanoparticle imaging for protein detection in cells
    Cognet, L
    Tardin, C
    Boyer, D
    Choquet, D
    Tamarat, P
    Lounis, B
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (20) : 11350 - 11355
  • [5] Sitica-Coated Gold Nanorods with a Gold Overcoat: Controlling Optical Properties by Controlling the Dimensions of a Gold-Silica-Gold Layered Nanoparticle
    Cong, Huaiping
    Toftegaard, Rasmus
    Arnbjerg, Jacob
    Ogilby, Peter R.
    [J]. LANGMUIR, 2010, 26 (06) : 4188 - 4195
  • [6] Crist R.M., 2012, Integr. Biol
  • [7] SYNTHESIS, STRUCTURE, AND PROPERTIES OF MODEL ORGANIC-SURFACES
    DUBOIS, LH
    NUZZO, RG
    [J]. ANNUAL REVIEW OF PHYSICAL CHEMISTRY, 1992, 43 : 437 - 463
  • [8] Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: Applications in oral cancer
    El-Sayed, IH
    Huang, XH
    El-Sayed, MA
    [J]. NANO LETTERS, 2005, 5 (05) : 829 - 834
  • [9] 'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG):: influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption
    Gref, R
    Lück, M
    Quellec, P
    Marchand, M
    Dellacherie, E
    Harnisch, S
    Blunk, T
    Müller, RH
    [J]. COLLOIDS AND SURFACES B-BIOINTERFACES, 2000, 18 (3-4) : 301 - 313
  • [10] Gold nanorods: Limitations on their synthesis and optical properties
    Jiang, XC
    Brioude, A
    Pileni, MP
    [J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2006, 277 (1-3) : 201 - 206
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