Anandamide effects on 5-HT3 receptors in vivo

被引：23
|
作者：
Racz, Ildiko
Bilkei-Gorzo, Andras
Markert, Astrid
Stamer, Friederike
Goethert, Manfred [2 ]
Zimmer, Andreas [1 ]
机构：
[1] Univ Bonn, Life & Brain Ctr, Inst Mol Psychiat, D-53105 Bonn, Germany
[2] Univ Bonn, Inst Pharmacol, D-53105 Bonn, Germany
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2008年 / 596卷 / 1-3期
关键词：
Cannabinoid receptors; 5-HT3; receptor; Anandamide; Delta(9)-tetrahydrocannabinol;
D O I：
10.1016/j.ejphar.2008.08.012
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Studies in knockout mouse strains have shown that some cannabimimetic effects persist in animals lacking cannabinoid CB1 and CB2 receptors. These residual effects are thought to result, in part, from a cannabinoid-modulation of ion channels. This study investigates the role of 5-HT3 receptors as a potential in vivo target for cannabinoids. Mice deficient in CB1 and CB2 receptors were treated with Delta(9)-tetrahydrocannabinol and anandamide, in the presence of the 5-HT3 antagonist ondansetron. We show that the cannabinoid receptor-independent anandamide analgesia, but not catalepsy, is completely blocked by ondansetron. Thus, 5-HT3 receptors seem to be involved in cannabinoid analgesia. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：98 / 101
页数：4
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