Sleep Pathology in Creutzfeldt-Jakob Disease

被引:25
作者
Kang, Peter [1 ]
de Bruin, Gabriela S. [1 ]
Wang, Leo H. [2 ]
Ward, Beth A. [3 ]
Ances, Beau M. [1 ]
Lim, Miranda M. [4 ,5 ,6 ,7 ,8 ]
Bucelli, Robert C. [1 ]
机构
[1] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA
[2] Univ Washington, Sch Med, Dept Neurol, Seattle, WA 98105 USA
[3] St Lukes Hosp, Sleep Med & Res Ctr, St Louis, MO USA
[4] VA Portland Hlth Care Syst, Sleep Disorders Clin, Portland, OR USA
[5] Oregon Hlth & Sci Univ, Dept Med, Portland, OR 97201 USA
[6] Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97201 USA
[7] Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97201 USA
[8] Oregon Hlth & Sci Univ, Oregon Inst Occupat Hlth Sci, Portland, OR 97201 USA
来源
JOURNAL OF CLINICAL SLEEP MEDICINE | 2016年 / 12卷 / 07期
关键词
Creutzfeldt-Jakob disease; dementia; neurodegeneration; prion diseases; sleep disorders; BEHAVIOR DISORDER; REM-SLEEP; ALZHEIMERS-DISEASE; NEURODEGENERATION; DIAGNOSIS; INSOMNIA; APNEA;
D O I
10.5664/jcsm.5944
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Study Objectives: Associations between sleep and neurodegenerative diseases have become increasingly evident. This study aims to characterize the prevalence and type of sleep pathology in Creutzfeldt-Jakob disease (CJD), a rapidly progressive, fatal neurodegenerative disease. Methods: In this observational cross-sectional cohort study, we performed a retrospective analysis of sleep signs and symptoms in a consecutive group of patients with definite CJD at a tertiary care medical center (n = 28). Polysomnography was performed in 14 patients. Results: Although only 5 of 28 patients carried a premorbid sleep diagnosis, signs/symptoms of sleep pathology were present in 25 patients. Eleven reported hypersomnia whereas 13 reported insomnia. Seven had restless legs symptoms and/or periodic limb movements of sleep, and nine reported parasomnias. Of the 14 patients who underwent polysomnography, 1 did not show sleep, 9 (69%) had poorly formed or absent sleep spindles and/or K-complexes, and 10 (77%) had sleep-disordered breathing. Of the 8 patients who experienced rapid eye movement (REM) sleep during the polysomnography, 3 (38%) showed REM sleep without atonia, and 2 patients met criteria for REM sleep behavior disorder. Median total sleep time was 226 (interquartile range [IQR] = 195-282) min. Median sleep efficiency was 58.5% (IQR = 41-65.5 %). Median REM time was 0.35% (IQR = 0-7.125%). Five patients (38%) demonstrated periodic limb movements during polysomnography. One case is presented. Conclusions: Sleep pathology is common in CJD, and screening for sleep pathology is indicated in the evaluation of patients with rapidly progressive dementias. Early identification and treatment of sleep pathology may provide an intervenable target for CJD.
引用
收藏
页码:1033 / 1039
页数:7
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