The structures of MsbA: Insight into ABC transporter-mediated multidrug efflux

被引：32

作者：

Reyes, CL ^{[1
]}

Ward, A ^{[1
]}

Yu, J ^{[1
]}

Chang, G ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92137 USA

来源：

FEBS LETTERS | 2006年 / 580卷 / 04期

关键词：

multidrug resistance; ABC transporter; membrane protein; X-ray crystallography; MsbA; P-glycoprotein; LmrA;

D O I：

10.1016/j.febslet.2005.11.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

ATP-binding cassette (ABC) transporters are integral membrane proteins that couple ATP hydrolysis to the transport of various molecules across cellular membranes. Found in both prokaryotes and eukaryotes, a sub-group of these transporters are involved in the efflux of hydrophobic drugs and lipids, causing anti-microbial and chemotherapeutic multidrug resistance. In this review, we examine recent structural and functional analysis of the ABC transporter MsbA and implications on the mechanism of multidrug efflux. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1042 / 1048

页数：7

共 50 条

[1] ABC Transporter-Mediated Multidrug-Resistant Cancer
Amawi, Haneen
Sim, Hong-May
Tiwari, Amit K.
Ambudkar, Suresh V.
Shukla, Suneet
DRUG TRANSPORTERS IN DRUG DISPOSITION, EFFECTS AND TOXICITY, 2019, 1141 : 549 - 580
[2] ABC Transporter-Mediated Multidrug Resistance in Prostate Cancer Cells
Famuyiwa, Toluleke O.
FASEB JOURNAL, 2019, 33
[3] Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance
Emily L. Giddings
Devin P. Champagne
Meng-Han Wu
Joshua M. Laffin
Tina M. Thornton
Felipe Valenca-Pereira
Rachel Culp-Hill
Karen A. Fortner
Natalia Romero
James East
Phoebe Cao
Hugo Arias-Pulido
Karatatiwant S. Sidhu
Brian Silverstrim
Yoonseok Kam
Shana Kelley
Mark Pereira
Susan E. Bates
Janice Y. Bunn
Steven N. Fiering
Dwight E. Matthews
Robert W. Robey
Domink Stich
Angelo D’Alessandro
Mercedes Rincon
Nature Communications, 12
[4] Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance
Giddings, Emily L.
Champagne, Devin P.
Wu, Meng-Han
Laffin, Joshua M.
Thornton, Tina M.
Valenca-Pereira, Felipe
Culp-Hill, Rachel
Fortner, Karen A.
Romero, Natalia
East, James
Cao, Phoebe
Arias-Pulido, Hugo
Sidhu, Karatatiwant S.
Silverstrim, Brian
Kam, Yoonseok
Kelley, Shana
Pereira, Mark
Bates, Susan E.
Bunn, Janice Y.
Fiering, Steven N.
Matthews, Dwight E.
Robey, Robert W.
Stich, Domink
D'Alessandro, Angelo
Rincon, Mercedes
NATURE COMMUNICATIONS, 2021, 12 (01)
[5] The modulation of ABC transporter-mediated multidrug resistance in cancer: A review of the past decade
Kathawala, Rishil J.
Gupta, Pranav
Ashby, Charles R., Jr.
Chen, Zhe-Sheng
DRUG RESISTANCE UPDATES, 2015, 18 : 1 - 17
[6] RNA TECHNOLOGIES FOR REVERSAL OF ABC TRANSPORTER-MEDIATED MULTIDRUG-RESISTANCE IN CANCER
Lage, Hermann
ANTICANCER RESEARCH, 2008, 28 (5C) : 3365 - 3365
[7] Natural medicinal compounds target signal transduction pathways to overcome ABC drug efflux transporter-mediated multidrug resistance in cancer
Bharathiraja, Pradhapsingh
Yadav, Priya
Sajid, Andaleeb
V. Ambudkar, Suresh
Prasad, N. Rajendra
DRUG RESISTANCE UPDATES, 2023, 71
[8] Characterization of multidrug transporter-mediated efflux of avermectins in human and mouse neuroblastoma cell lines
Dalzell, Abigail M.
Mistry, Pratibha
Wright, Jayne
Williams, Faith. M.
Brown, Colin. D. A.
TOXICOLOGY LETTERS, 2015, 235 (03) : 189 - 198
[9] Copper efflux transporter-mediated resistance to cisplatin
Mathews, Ryan A.
Safaei, Roohangiz
Howell, Stephen B.
CANCER RESEARCH, 2012, 72
[10] ABC transporter-mediated MXR mechanism in fish embryos and its potential role in the efflux of nanoparticles
Yin, Jian
Hu, Jia
Deng, Xudong
Zheng, Yu
Tian, Jingjing
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2023, 263

← 1 2 3 4 5 →