The T-Cell Response to HIV

被引：128

作者：

Walker, Bruce ^{[1
,2
]}

McMichael, Andrew ^{[3
]}

机构：

[1] MIT, Ragon Inst MGH, Charlestown, MA 02129 USA

[2] Harvard Mass Gen Hosp E, Charlestown, MA 02129 USA

[3] Univ Oxford, Weatherall Inst Mol Med, Oxford OX3 9DS, England

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2012年 / 2卷 / 11期

关键词：

CYTOTOXIC LYMPHOCYTES-T; VIRUS TYPE-1 INFECTION; REPLICATION CAPACITY; IMMUNE-RESPONSES; VIRAL LOAD; CLADE-C; ESCAPE MUTATIONS; SECONDARY EXPANSION; MAJOR DETERMINANTS; ELITE CONTROLLERS;

D O I：

10.1101/cshperspect.a007054

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

HIV is a disease in which the original clinical observations of severe opportunistic infections gave the first clues regarding the underlying pathology, namely that HIV is essentially an infection of the immune system. HIV infects and deletes CD4(+) T cells that normally coordinate the adaptive T- and B-cell response to defend against intracellular pathogens. The immune defect is immediate and profound: At the time of acute infection with an AIDS virus, typically more than half of the gut-associated CD4(+) T cells are depleted, leaving a damaged immune system to contend with a life-long infection.

引用

页数：19

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